Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1524754..1525394 Replicon chromosome
Accession NZ_CP021731
Organism Azoarcus sp. DN11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDA09_RS07005 Protein ID WP_121427963.1
Coordinates 1524966..1525394 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDA09_RS07000 Protein ID WP_121427962.1
Coordinates 1524754..1524966 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDA09_RS06980 1520265..1521587 - 1323 WP_121427554.1 IS1182 family transposase -
CDA09_RS06985 1521662..1522297 - 636 WP_121430764.1 DDE-type integrase/transposase/recombinase -
CDA09_RS23120 1522518..1522817 - 300 WP_128106536.1 hypothetical protein -
CDA09_RS06990 1523231..1523905 - 675 WP_121430765.1 hypothetical protein -
CDA09_RS06995 1524006..1524644 + 639 WP_121427961.1 DUF429 domain-containing protein -
CDA09_RS07000 1524754..1524966 + 213 WP_121427962.1 DNA-binding protein Antitoxin
CDA09_RS07005 1524966..1525394 + 429 WP_121427963.1 type II toxin-antitoxin system VapC family toxin Toxin
CDA09_RS07010 1525525..1526328 - 804 WP_121430766.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CDA09_RS07015 1526385..1527197 - 813 WP_121427964.1 hypothetical protein -
CDA09_RS07020 1527317..1527781 - 465 WP_121427965.1 hypothetical protein -
CDA09_RS07025 1527808..1528323 - 516 WP_121427966.1 hypothetical protein -
CDA09_RS07030 1529221..1529538 + 318 WP_174718482.1 metal-sulfur cluster assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1520265..1521587 1322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15838.98 Da        Isoelectric Point: 4.7278

>T77186 WP_121427963.1 NZ_CP021731:1524966-1525394 [Azoarcus sp. DN11]
MYLLDTNIISELRKGGRANPGVTAFFATLAAEDIYLSVQTVGEIRRGVETIRKRGDREQANRLEAWLDLVIADYSDRILG
FDLDCAQVWGKLMSPSPQHPVDKQIAAIALIYDLTVVTRNTEDFESTGVRNINPFSSPQPIT

Download         Length: 429 bp

>T77186 NZ_CP021731:1524966-1525394 [Azoarcus sp. DN11]
ATGTACCTGCTCGACACCAACATCATCAGCGAGCTGCGCAAAGGCGGGCGCGCCAATCCCGGCGTTACCGCCTTTTTTGC
GACTCTGGCAGCGGAAGACATCTATCTATCGGTGCAGACCGTCGGCGAGATTCGTCGCGGCGTCGAGACCATCCGTAAAC
GAGGTGACCGCGAGCAGGCGAATCGCCTCGAGGCCTGGCTGGACCTGGTGATTGCCGACTACTCGGACCGGATACTGGGC
TTCGACCTCGACTGCGCGCAGGTATGGGGAAAGCTCATGTCGCCGAGTCCCCAGCATCCCGTCGACAAGCAGATTGCTGC
CATTGCGCTCATCTACGACCTGACGGTGGTCACGCGTAACACGGAAGATTTCGAGTCCACCGGAGTGCGGAACATCAATC
CCTTCAGCTCGCCTCAGCCGATAACCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7854.91 Da        Isoelectric Point: 7.2051

>AT77186 WP_121427962.1 NZ_CP021731:1524754-1524966 [Azoarcus sp. DN11]
MATNLVVRNVEPEVAQALKEAAARHGRSAEAEHREILRVALSRPPRRTFKDVLAIMPDVGTDEDFNFRQG

Download         Length: 213 bp

>AT77186 NZ_CP021731:1524754-1524966 [Azoarcus sp. DN11]
ATGGCGACCAATCTTGTTGTGCGCAACGTCGAGCCCGAGGTCGCGCAGGCCTTGAAGGAGGCGGCGGCTCGGCACGGGCG
TAGTGCTGAAGCGGAGCACCGCGAAATTTTGCGGGTGGCCCTTTCGCGACCGCCTCGCCGAACCTTCAAGGACGTGCTTG
CGATCATGCCCGACGTGGGTACCGACGAAGACTTCAACTTCAGGCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References