Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4627031..4627547 Replicon chromosome
Accession NZ_CP021718
Organism Klebsiella pneumoniae strain AR_0129

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM376_RS25905 Protein ID WP_002886902.1
Coordinates 4627263..4627547 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM376_RS25900 Protein ID WP_002886901.1
Coordinates 4627031..4627273 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM376_RS25885 4623060..4623800 + 741 WP_002886899.1 KDGP aldolase family protein -
AM376_RS25890 4623866..4625020 + 1155 WP_002886900.1 lactonase family protein -
AM376_RS25895 4625043..4626953 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AM376_RS25900 4627031..4627273 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM376_RS25905 4627263..4627547 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM376_RS25910 4627551..4628015 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM376_RS25915 4628256..4630394 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AM376_RS25920 4630751..4631494 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM376_RS30730 4631497..4631670 - 174 WP_002886906.1 hypothetical protein -
AM376_RS25925 4631755..4632063 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T77120 WP_002886902.1 NZ_CP021718:4627263-4627547 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T77120 NZ_CP021718:4627263-4627547 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT77120 WP_002886901.1 NZ_CP021718:4627031-4627273 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT77120 NZ_CP021718:4627031-4627273 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References