Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4986087..4986612 Replicon chromosome
Accession NZ_CP021707
Organism Streptomyces sp. S063

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CCZ36_RS23185 Protein ID WP_069743864.1
Coordinates 4986087..4986350 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CCZ36_RS23190 Protein ID WP_069739090.1
Coordinates 4986343..4986612 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ36_RS23160 4981989..4982741 + 753 WP_069739111.1 ROK family protein -
CCZ36_RS23165 4982879..4983460 - 582 WP_128819695.1 hypothetical protein -
CCZ36_RS23170 4983782..4984870 + 1089 WP_128818479.1 redox-regulated ATPase YchF -
CCZ36_RS23175 4985086..4985370 + 285 WP_006138089.1 hypothetical protein -
CCZ36_RS23180 4985352..4985765 + 414 WP_128818480.1 DNA-binding protein -
CCZ36_RS23185 4986087..4986350 - 264 WP_069743864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCZ36_RS23190 4986343..4986612 - 270 WP_069739090.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CCZ36_RS23195 4986979..4987455 + 477 WP_128818481.1 hemerythrin domain-containing protein -
CCZ36_RS23200 4987583..4988002 + 420 WP_079149667.1 MarR family winged helix-turn-helix transcriptional regulator -
CCZ36_RS23205 4987972..4988631 - 660 WP_128819697.1 2-phospho-L-lactate guanylyltransferase -
CCZ36_RS23210 4988649..4989161 - 513 WP_128818482.1 nuclear transport factor 2 family protein -
CCZ36_RS23215 4989282..4989536 + 255 WP_069739086.1 acyl carrier protein -
CCZ36_RS23220 4989523..4990743 - 1221 WP_128818483.1 acyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.54 Da        Isoelectric Point: 8.5042

>T77079 WP_069743864.1 NZ_CP021707:c4986350-4986087 [Streptomyces sp. S063]
VSEYRTVFRPEAQTELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RATVYDT

Download         Length: 264 bp

>T77079 NZ_CP021707:c4986350-4986087 [Streptomyces sp. S063]
GTGAGTGAGTACCGAACCGTCTTCCGACCCGAGGCTCAGACCGAGCTCCGGAAGATCCCACGCGACATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGAGCGATCCCCTCGGCTTCAACACCACCGCGCTCGTGTCGCAGCCGGAACGCCGTC
GGCTGCGCGTCGGCGACTACCGGGTCGTCTACACAATCGACAACGGAGAGCTCGTGGTGTGGGTCGTACACGTCGGACAT
CGCGCCACCGTTTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10283.78 Da        Isoelectric Point: 4.9507

>AT77079 WP_069739090.1 NZ_CP021707:c4986612-4986343 [Streptomyces sp. S063]
MTQPLPIESIRDVRAHLAEVVERADRHDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAVGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT77079 NZ_CP021707:c4986612-4986343 [Streptomyces sp. S063]
ATGACGCAGCCGCTACCCATAGAGTCCATCCGCGACGTGCGCGCCCACCTAGCGGAAGTCGTGGAGCGCGCCGACCGCCA
CGACGTGCCCACGGTCATCACGCGCCGAGGGAAGGAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCTGTCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References