Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 77825..78350 Replicon plasmid tig00000183
Accession NZ_CP021698
Organism Klebsiella pneumoniae strain AR_0158

Toxin (Protein)


Gene name ccdB Uniprot ID A0A9E1GGX2
Locus tag AM404_RS27315 Protein ID WP_016946795.1
Coordinates 77825..78130 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A9E1GDP8
Locus tag AM404_RS27320 Protein ID WP_004197642.1
Coordinates 78132..78350 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM404_RS27290 73701..73970 + 270 WP_000339857.1 hypothetical protein -
AM404_RS27295 74255..75121 - 867 WP_004118283.1 replication initiation protein -
AM404_RS30300 75656..75760 + 105 WP_032409716.1 hypothetical protein -
AM404_RS27300 75889..76146 + 258 WP_000764642.1 hypothetical protein -
AM404_RS27305 76204..76980 - 777 WP_049245386.1 site-specific integrase -
AM404_RS27310 77284..77667 - 384 WP_063945279.1 hypothetical protein -
AM404_RS27315 77825..78130 - 306 WP_016946795.1 type II toxin-antitoxin system toxin CcdB Toxin
AM404_RS27320 78132..78350 - 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
AM404_RS27335 78906..79499 + 594 WP_123806157.1 hypothetical protein -
AM404_RS27340 79640..80668 + 1029 WP_001568023.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / dfrA14 - 1..87411 87411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11548.22 Da        Isoelectric Point: 5.6831

>T77076 WP_016946795.1 NZ_CP021698:c78130-77825 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDDSYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T77076 NZ_CP021698:c78130-77825 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8376.34 Da        Isoelectric Point: 4.7405

>AT77076 WP_004197642.1 NZ_CP021698:c78350-78132 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT77076 NZ_CP021698:c78350-78132 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGAATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References