Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4213571..4214087 Replicon chromosome
Accession NZ_CP021696
Organism Klebsiella pneumoniae strain AR_0158

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag AM404_RS21295 Protein ID WP_009309309.1
Coordinates 4213803..4214087 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM404_RS21290 Protein ID WP_002886901.1
Coordinates 4213571..4213813 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM404_RS21275 4209599..4210339 + 741 WP_009309313.1 KDGP aldolase family protein -
AM404_RS21280 4210406..4211560 + 1155 WP_009309312.1 lactonase family protein -
AM404_RS21285 4211583..4213493 + 1911 WP_087728388.1 BglG family transcription antiterminator -
AM404_RS21290 4213571..4213813 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM404_RS21295 4213803..4214087 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM404_RS21300 4214091..4214555 - 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM404_RS21305 4214885..4217023 - 2139 WP_009309308.1 anaerobic ribonucleoside-triphosphate reductase -
AM404_RS21310 4217380..4218123 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM404_RS30175 4218126..4218299 - 174 WP_032408826.1 hypothetical protein -
AM404_RS21315 4218384..4218692 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T77069 WP_009309309.1 NZ_CP021696:4213803-4214087 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T77069 NZ_CP021696:4213803-4214087 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT77069 WP_002886901.1 NZ_CP021696:4213571-4213813 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT77069 NZ_CP021696:4213571-4213813 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References