Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3005076..3005779 Replicon chromosome
Accession NZ_CP021696
Organism Klebsiella pneumoniae strain AR_0158

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag AM404_RS15180 Protein ID WP_009309675.1
Coordinates 3005076..3005417 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag AM404_RS15185 Protein ID WP_009309674.1
Coordinates 3005438..3005779 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM404_RS15160 3000303..3002048 + 1746 WP_004149864.1 DNA primase -
AM404_RS15165 3002267..3004108 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
AM404_RS15170 3004208..3004714 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
AM404_RS15180 3005076..3005417 - 342 WP_009309675.1 TA system toxin CbtA family protein Toxin
AM404_RS15185 3005438..3005779 - 342 WP_009309674.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM404_RS15190 3005790..3006332 - 543 WP_009309673.1 DNA repair protein RadC -
AM404_RS15195 3006345..3006787 - 443 Protein_2923 antirestriction protein -
AM404_RS15200 3006818..3007639 - 822 WP_009309670.1 DUF945 domain-containing protein -
AM404_RS15205 3007837..3008709 - 873 WP_196983271.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12822.76 Da        Isoelectric Point: 9.6542

>T77065 WP_009309675.1 NZ_CP021696:c3005417-3005076 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAEITLADAVNFLVDKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Download         Length: 342 bp

>T77065 NZ_CP021696:c3005417-3005076 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGTGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGCCTGGCAAATGTTACTGAC
ACGCCTACTGGAACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACAGTTATTAAGGAACATATTG
ATGCCGAGATTACCCTGGCTGATGCAGTCAACTTCTTGGTGGATAAGTACGGACTGGTTCGTATCGATCGCAGGGGGTTT
AACTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTCTGCGAGCACGACAGGCAACTGGCTTGCTGCGACGGAG
CCGTAATAATGCTGTATCGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12735.41 Da        Isoelectric Point: 6.3157

>AT77065 WP_009309674.1 NZ_CP021696:c3005779-3005438 [Klebsiella pneumoniae]
MKSTESENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGAFSNAESLKLDEVFPRFISQMESMLTIGEMNPHH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT77065 NZ_CP021696:c3005779-3005438 [Klebsiella pneumoniae]
ATGAAATCTACTGAGTCAGAGAACGATTTATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGCATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGTTGACCATTGGTGAAATGAATCCTCACCAT
GCCCACTGCGTCACCCTATACCACAACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References