Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 344550..345151 Replicon chromosome
Accession NZ_CP021694
Organism Proteus mirabilis strain AR_0155

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag AM402_RS01840 Protein ID WP_036895893.1
Coordinates 344768..345151 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag AM402_RS01835 Protein ID WP_004246496.1
Coordinates 344550..344771 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM402_RS01810 340335..340793 + 459 WP_004246490.1 dUTP diphosphatase -
AM402_RS01815 340913..341518 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
AM402_RS01820 341837..342481 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
AM402_RS01825 342563..343279 - 717 WP_004249760.1 ribonuclease PH -
AM402_RS01830 343406..344269 + 864 WP_004249947.1 YicC family protein -
AM402_RS01835 344550..344771 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AM402_RS01840 344768..345151 + 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AM402_RS01845 345558..345872 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
AM402_RS01850 346172..347071 - 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
AM402_RS01855 347180..347917 + 738 WP_004249950.1 sel1 repeat family protein -
AM402_RS01860 348013..348471 - 459 Protein_345 GNAT family N-acetyltransferase -
AM402_RS01865 348600..350087 + 1488 WP_087726303.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T77047 WP_036895893.1 NZ_CP021694:344768-345151 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T77047 NZ_CP021694:344768-345151 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT77047 WP_004246496.1 NZ_CP021694:344550-344771 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT77047 NZ_CP021694:344550-344771 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References