Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2099559..2100197 Replicon chromosome
Accession NZ_CP021683
Organism Escherichia coli strain AR_0162

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag AM408_RS11780 Protein ID WP_001447010.1
Coordinates 2100021..2100197 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM408_RS11775 Protein ID WP_001270286.1
Coordinates 2099559..2099975 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM408_RS11755 2094711..2095652 - 942 WP_001251304.1 ABC transporter permease -
AM408_RS11760 2095653..2096666 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
AM408_RS11765 2096684..2097829 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
AM408_RS11770 2098074..2099480 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
AM408_RS11775 2099559..2099975 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
AM408_RS11780 2100021..2100197 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
AM408_RS11785 2100419..2100649 + 231 WP_000494244.1 YncJ family protein -
AM408_RS11790 2100741..2102702 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
AM408_RS11795 2102775..2103311 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
AM408_RS11800 2103364..2104578 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T76948 WP_001447010.1 NZ_CP021683:c2100197-2100021 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T76948 NZ_CP021683:c2100197-2100021 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT76948 WP_001270286.1 NZ_CP021683:c2099975-2099559 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT76948 NZ_CP021683:c2099975-2099559 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References