Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4156705..4157341 Replicon chromosome
Accession NZ_CP021669
Organism Bacillus licheniformis strain SRCM100141

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag S100141_RS21780 Protein ID WP_003179128.1
Coordinates 4156991..4157341 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag S100141_RS21775 Protein ID WP_006638778.1
Coordinates 4156705..4156986 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S100141_RS21755 4151820..4153301 + 1482 WP_009330132.1 PH domain-containing protein -
S100141_RS21760 4153298..4153897 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
S100141_RS21765 4154240..4155199 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
S100141_RS21770 4155424..4156593 + 1170 WP_026080763.1 alanine racemase -
S100141_RS21775 4156705..4156986 + 282 WP_006638778.1 hypothetical protein Antitoxin
S100141_RS21780 4156991..4157341 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
S100141_RS21785 4157459..4158286 + 828 WP_061578564.1 RsbT co-antagonist protein RsbRA -
S100141_RS21790 4158290..4158655 + 366 WP_003179132.1 STAS domain-containing protein -
S100141_RS21795 4158658..4159059 + 402 WP_003179135.1 anti-sigma regulatory factor -
S100141_RS21800 4159070..4160077 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
S100141_RS21805 4160136..4160462 + 327 WP_003179140.1 anti-sigma factor antagonist -
S100141_RS21810 4160462..4160947 + 486 WP_003179142.1 anti-sigma B factor RsbW -
S100141_RS21815 4160913..4161704 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
S100141_RS21820 4161701..4162300 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T76927 WP_003179128.1 NZ_CP021669:4156991-4157341 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T76927 NZ_CP021669:4156991-4157341 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT76927 WP_006638778.1 NZ_CP021669:4156705-4156986 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT76927 NZ_CP021669:4156705-4156986 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References