Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 59894..60693 Replicon plasmid p5D_Fsymbiotica-2
Accession NZ_CP021661
Organism Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag CCS41_RS14895 Protein ID WP_119797952.1
Coordinates 60169..60693 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag CCS41_RS14890 Protein ID WP_119797951.1
Coordinates 59894..60172 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS41_RS14870 55318..55524 - 207 WP_119797948.1 hypothetical protein -
CCS41_RS15815 55523..55822 + 300 WP_205411526.1 hypothetical protein -
CCS41_RS15820 56042..56197 - 156 WP_162860129.1 hypothetical protein -
CCS41_RS14875 56194..56898 - 705 WP_119797949.1 PAS domain-containing protein -
CCS41_RS14880 58011..58739 + 729 WP_119797950.1 PAS domain-containing protein -
CCS41_RS14885 58747..59506 - 760 Protein_81 IS5 family transposase -
CCS41_RS14890 59894..60172 + 279 WP_119797951.1 DUF1778 domain-containing protein Antitoxin
CCS41_RS14895 60169..60693 + 525 WP_119797952.1 GNAT family N-acetyltransferase Toxin
CCS41_RS14900 60694..61305 + 612 WP_119797953.1 hypothetical protein -
CCS41_RS14910 61512..61913 - 402 WP_119797954.1 type II toxin-antitoxin system VapC family toxin -
CCS41_RS14915 61910..62167 - 258 WP_119797955.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CCS41_RS14920 62326..63285 - 960 WP_162859989.1 IS110 family transposase -
CCS41_RS14925 63546..63905 + 360 Protein_88 ISKra4 family transposase -
CCS41_RS14930 64239..64568 - 330 WP_119797956.1 HigA family addiction module antidote protein -
CCS41_RS14935 64581..64871 - 291 WP_119797981.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91823 91823
- flank IS/Tn - - 63606..63905 299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 18778.69 Da        Isoelectric Point: 9.8503

>T76922 WP_119797952.1 NZ_CP021661:60169-60693 [Candidatus Fukatsuia symbiotica]
MTLPGWHEAPIGKHHDRAAFDCGDDTLNQFLHRHARQSHEKGGAKTYLAVSDSNQKVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAVDISVQGKRLGGQLLLAAGRRCLLVATQAGGVALMIDAKSEQVAHWYASYGAVPLLDAPLSLLLP
LKTIHAALTTAGKL

Download         Length: 525 bp

>T76922 NZ_CP021661:60169-60693 [Candidatus Fukatsuia symbiotica]
ATGACGTTACCAGGTTGGCACGAAGCTCCCATAGGTAAACATCATGATCGCGCAGCCTTCGATTGTGGTGATGATACGTT
GAATCAATTTTTACATCGTCATGCGCGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCTGTTAGTGACAGCA
ATCAAAAGGTTTTGGGTTACTACAGCCTTAGCCCCGCCTCCATTGCTTACGAACGCGCCCCGGAGGTGATAAAACGTGGT
TTGGCTCGGCATGAAGTGCCCGTATTTCGGCTTGGCCGTCTGGCTGTAGATATTTCAGTACAGGGGAAAAGGCTTGGTGG
GCAGTTATTACTTGCAGCAGGGCGACGCTGCCTTTTGGTTGCCACACAGGCAGGCGGTGTCGCGCTTATGATTGATGCTA
AGAGTGAGCAAGTAGCTCATTGGTATGCGAGTTATGGTGCTGTTCCACTGTTAGATGCGCCTTTGTCTCTGTTGTTGCCG
TTAAAAACGATTCATGCTGCACTTACTACAGCAGGGAAACTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10424.05 Da        Isoelectric Point: 4.8047

>AT76922 WP_119797951.1 NZ_CP021661:59894-60172 [Candidatus Fukatsuia symbiotica]
MPQLLVETNDRMSLRIASEEKSLLIRAAAIQHTNLTEFVIRNVVSVARKIIDDNERLELTERDSLHVLELLDNPPTPNDK
LMTAAFSLPMLS

Download         Length: 279 bp

>AT76922 NZ_CP021661:59894-60172 [Candidatus Fukatsuia symbiotica]
ATGCCTCAGCTCCTAGTAGAAACCAATGACCGTATGTCATTGCGTATTGCCTCGGAAGAAAAATCGTTGTTAATACGCGC
AGCCGCTATACAGCATACTAACCTGACTGAATTTGTAATTCGTAATGTGGTGTCGGTAGCACGAAAAATTATCGACGATA
ACGAACGGCTGGAACTCACAGAGAGAGACAGTTTACATGTACTGGAGCTTTTGGATAATCCGCCGACACCCAACGATAAG
TTGATGACGGCTGCATTTTCTTTGCCGATGCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References