Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-higA/PIN_Sll0205-like-HigA
Location 43158..43924 Replicon plasmid p5D_Fsymbiotica-2
Accession NZ_CP021661
Organism Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCS41_RS14785 Protein ID WP_119797935.1
Coordinates 43529..43924 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCS41_RS14780 Protein ID WP_119797934.1
Coordinates 43158..43535 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS41_RS14745 38741..39313 - 573 WP_119797928.1 TrbI/VirB10 family protein -
CCS41_RS15810 39601..39885 + 285 WP_162860127.1 hypothetical protein -
CCS41_RS14760 39981..40784 - 804 WP_119797931.1 TrbG/VirB9 family P-type conjugative transfer protein -
CCS41_RS14765 40789..41589 - 801 WP_119797932.1 type IV secretion system protein -
CCS41_RS14770 41802..42752 - 951 WP_119797933.1 type IV secretion system protein -
CCS41_RS14775 42776..43117 - 342 WP_039908292.1 hypothetical protein -
CCS41_RS14780 43158..43535 - 378 WP_119797934.1 helix-turn-helix domain-containing protein Antitoxin
CCS41_RS14785 43529..43924 - 396 WP_119797935.1 type II toxin-antitoxin system VapC family toxin Toxin
CCS41_RS14790 43921..44157 - 237 WP_006705272.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CCS41_RS14795 44239..44496 - 258 WP_119797936.1 hypothetical protein -
CCS41_RS14800 44537..44947 - 411 WP_119797937.1 helix-turn-helix domain-containing protein -
CCS41_RS14805 44944..45255 - 312 WP_119797938.1 type II toxin-antitoxin system HigB family toxin -
CCS41_RS14810 45333..45566 - 234 WP_119797939.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CCS41_RS14815 45631..46323 - 693 WP_119797940.1 type IV secretion system protein -
CCS41_RS14820 46320..48716 - 2397 WP_119797941.1 VirB4 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91823 91823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(3-131)

Antitoxin

Cro/C1-type helix-turn-helix domain

(70-119)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14744.12 Da        Isoelectric Point: 4.7628

>T76919 WP_119797935.1 NZ_CP021661:c43924-43529 [Candidatus Fukatsuia symbiotica]
MIVLDTHVLVWWVADDSMLSVTAKAAIEEEQAKGEIIISSISAWEIAMLVQRERLLLSMDVDSWLATVSQIDAVRFVPVD
TEVATKSVELPGEFHKDPSDRMIVATARKLAVPLVTKDEKIRTYAHVRTIW

Download         Length: 396 bp

>T76919 NZ_CP021661:c43924-43529 [Candidatus Fukatsuia symbiotica]
ATGATCGTTTTGGACACGCATGTGTTGGTTTGGTGGGTAGCAGACGATTCAATGCTAAGCGTAACAGCAAAGGCGGCAAT
TGAAGAAGAACAGGCCAAAGGTGAGATCATTATATCCAGCATATCGGCCTGGGAAATTGCAATGTTAGTCCAGCGCGAGA
GATTGCTGCTGTCGATGGACGTAGATAGTTGGCTTGCGACAGTCTCACAAATCGATGCGGTGCGCTTTGTGCCGGTAGAC
ACAGAGGTAGCGACAAAATCTGTTGAGCTTCCTGGTGAATTTCATAAAGACCCATCAGACCGTATGATTGTAGCGACTGC
ACGTAAGCTGGCAGTACCACTCGTAACCAAGGACGAGAAAATTCGTACCTATGCTCATGTAAGAACAATTTGGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14107.01 Da        Isoelectric Point: 4.6034

>AT76919 WP_119797934.1 NZ_CP021661:c43535-43158 [Candidatus Fukatsuia symbiotica]
MVTAVPLLGGSHSQSDYKAALELVDYLIENDDENPLIDILAVKIAEYEEHNEQFYEFNKALEGMSTGVTALRVLMDQYNL
KQTDLKNEIGSRSLVSQILSGKRSLTIDHIRSLSARFNVRCEVFI

Download         Length: 378 bp

>AT76919 NZ_CP021661:c43535-43158 [Candidatus Fukatsuia symbiotica]
TTGGTGACAGCCGTTCCACTATTGGGGGGAAGTCATTCTCAATCAGATTATAAAGCGGCGCTTGAATTAGTCGATTATCT
TATTGAAAATGATGATGAAAATCCTCTAATTGATATTTTGGCTGTCAAGATCGCGGAATATGAAGAACATAACGAACAAT
TTTATGAATTTAATAAGGCACTTGAAGGGATGTCCACTGGAGTGACAGCGCTACGGGTATTAATGGATCAATATAATTTA
AAACAAACTGATTTAAAGAATGAGATAGGTTCGAGGTCGTTGGTTAGTCAAATACTGAGTGGCAAGCGCTCATTAACTAT
CGATCATATTAGATCTCTATCCGCGCGTTTTAACGTGCGCTGTGAAGTATTTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References