Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 142442..143232 Replicon plasmid p5D_Fsymbiotica-1
Accession NZ_CP021660
Organism Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag CCS41_RS14460 Protein ID WP_119797883.1
Coordinates 142732..143232 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag CCS41_RS14455 Protein ID WP_119797882.1
Coordinates 142442..142735 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS41_RS14420 137938..138960 - 1023 WP_119797794.1 IS630 family transposase -
CCS41_RS14425 139060..139809 + 750 Protein_132 transposase -
CCS41_RS14430 140143..140772 + 630 WP_119797879.1 AAA family ATPase -
CCS41_RS14435 140769..141002 + 234 WP_119797880.1 hypothetical protein -
CCS41_RS14440 141102..141463 + 362 Protein_135 IS630 family transposase -
CCS41_RS14445 141565..141876 + 312 WP_119797893.1 type II toxin-antitoxin system HigB family toxin -
CCS41_RS14450 141873..142337 + 465 WP_119797881.1 helix-turn-helix domain-containing protein -
CCS41_RS14455 142442..142735 + 294 WP_119797882.1 DUF1778 domain-containing protein Antitoxin
CCS41_RS14460 142732..143232 + 501 WP_119797883.1 GNAT family N-acetyltransferase Toxin
CCS41_RS14465 143389..143703 - 315 WP_119797884.1 helix-turn-helix domain-containing protein -
CCS41_RS14475 143849..144367 - 519 WP_119797885.1 type II toxin-antitoxin system YhaV family toxin -
CCS41_RS14480 144376..144741 - 366 WP_119797886.1 type II toxin-antitoxin system PrlF family antitoxin -
CCS41_RS14485 144933..145914 + 982 Protein_143 transposase -
CCS41_RS14490 146034..146303 - 270 WP_119797887.1 hypothetical protein -
CCS41_RS14495 146303..146938 - 636 WP_119797888.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..148316 148316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-89)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18013.08 Da        Isoelectric Point: 10.4587

>T76916 WP_119797883.1 NZ_CP021660:142732-143232 [Candidatus Fukatsuia symbiotica]
MIISAPEPLREQHEVSLFSSGVASLDNWLAQKALKNQRSGASRTFVVCGNNNVLAYYALSAGVVAGKNAVGRFKRNMPDP
IPVVVLGRLAIDKRFQGKGWGRALIRDAGLRLIYAADVMGIRGMMVHALSNDAKNFYKKVGFEASPLDPLLLMVTLADLK
SILVSD

Download         Length: 501 bp

>T76916 NZ_CP021660:142732-143232 [Candidatus Fukatsuia symbiotica]
ATGATTATTTCTGCTCCTGAACCTTTAAGGGAACAGCACGAGGTTTCTTTATTTAGCTCTGGTGTGGCGAGTCTTGATAA
CTGGCTTGCCCAGAAGGCGTTAAAAAATCAGAGAAGTGGTGCTTCACGAACATTTGTAGTTTGTGGAAATAATAATGTGC
TGGCTTATTATGCATTATCAGCCGGTGTCGTGGCTGGCAAAAATGCTGTAGGGCGTTTCAAGCGTAATATGCCTGATCCT
ATTCCAGTTGTGGTACTTGGACGATTGGCTATTGATAAACGTTTTCAAGGGAAAGGGTGGGGTCGAGCGTTGATAAGAGA
TGCAGGATTGCGTTTAATTTATGCAGCTGATGTGATGGGTATTCGTGGAATGATGGTTCATGCATTGTCTAACGATGCGA
AAAATTTTTATAAAAAAGTCGGCTTTGAAGCATCCCCTCTGGATCCCTTACTGTTAATGGTTACGTTAGCTGATTTGAAA
AGTATTTTAGTTAGTGATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10989.51 Da        Isoelectric Point: 4.9166

>AT76916 WP_119797882.1 NZ_CP021660:142442-142735 [Candidatus Fukatsuia symbiotica]
VVTLACSTARRETLNIRIKSEEKDLIDRAALTKGKNRTDFILEAARYAAEEALLEQIIIMASPEVHSEFLTRLDMSAAPN
ERLKQTMQKSAPWDNDE

Download         Length: 294 bp

>AT76916 NZ_CP021660:142442-142735 [Candidatus Fukatsuia symbiotica]
GTGGTTACTTTAGCTTGTAGTACAGCAAGACGCGAAACACTTAATATTCGCATCAAATCGGAAGAAAAAGACCTGATTGA
TAGGGCTGCTCTGACTAAAGGTAAAAATAGAACAGATTTCATCCTTGAGGCTGCCCGTTATGCGGCTGAAGAAGCGCTGT
TAGAGCAGATTATTATCATGGCTAGCCCAGAAGTCCATTCAGAATTTCTTACGAGGTTAGATATGTCTGCGGCTCCTAAC
GAGCGTTTGAAGCAGACGATGCAAAAATCTGCACCCTGGGACAACGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References