Detailed information of TA system TA076912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2623403..2624036
• Replicon: chromosome
• Accession: NZ_CP021659
• Organism: Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCS41_RS12790
• Protein ID: WP_119797652.1
• Coordinates: 2623626..2624036 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CCS41_RS12785
• Protein ID: WP_119797651.1
• Coordinates: 2623403..2623639 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS41_RS12760	2619370..2619825	+	456	WP_119797647.1	Hsp20 family protein	-
CCS41_RS12765	2620164..2620772	+	609	WP_119797648.1	hypothetical protein	-
CCS41_RS12770	2620757..2621860	+	1104	WP_162860078.1	endonuclease/exonuclease/phosphatase family protein	-
CCS41_RS12775	2622173..2622484	+	312	WP_205411432.1	helix-turn-helix domain-containing protein	-
CCS41_RS12780	2622570..2622851	+	282	WP_119797650.1	integrase core domain-containing protein	-
CCS41_RS12785	2623403..2623639	+	237	WP_119797651.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CCS41_RS12790	2623626..2624036	+	411	WP_119797652.1	PIN domain-containing protein	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2490566..2677982	187416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-46)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15653.29 Da
• Isoelectric Point: 6.8370

>T76912 WP_119797652.1 NZ_CP021659:2623626-2624036 [Candidatus Fukatsuia symbiotica]
MSAIKSKMFIDSNILLYLLSQDTAKADTVEMLLKGKPTISVQVLNEVTSVCVRKLKMSWQEIGQFLELVRNFCRVVPLTE
AIHDGARQIAERHYLSFYDDCIVAAAMTERCRTLYTEDMHHGLLIEENLRLCNPFR

Nucleotide

• Length: 411 bp

>T76912 NZ_CP021659:2623626-2624036 [Candidatus Fukatsuia symbiotica]
ATGAGCGCAATTAAGAGTAAGATGTTTATTGACAGTAATATCCTGCTTTATCTACTATCGCAAGATACCGCTAAAGCTGA
TACCGTAGAAATGTTACTTAAGGGAAAGCCAACCATCAGTGTGCAGGTACTTAATGAAGTGACATCGGTTTGCGTTCGCA
AGCTCAAGATGAGTTGGCAAGAAATCGGACAATTTCTGGAATTAGTACGTAATTTTTGCCGTGTGGTGCCACTAACTGAA
GCAATACATGATGGTGCTCGCCAAATTGCAGAACGTCATTATCTGTCATTCTACGATGACTGTATTGTCGCCGCTGCCAT
GACAGAACGTTGCCGTACCCTTTATACTGAAGATATGCATCATGGTCTTCTGATTGAAGAAAATTTACGGCTTTGCAATC
CATTCAGGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9174.59 Da
• Isoelectric Point: 10.4718

>AT76912 WP_119797651.1 NZ_CP021659:2623403-2623639 [Candidatus Fukatsuia symbiotica]
MQVAKWGNSLAVRLPSELIKLLELREGDSIEIIVDEPRVFSVRKKQKVDTNLLERLRTFRGKLPVNFHFNRDEANERN

Nucleotide

• Length: 237 bp

>AT76912 NZ_CP021659:2623403-2623639 [Candidatus Fukatsuia symbiotica]
ATGCAAGTAGCAAAGTGGGGTAATAGTTTGGCTGTACGCCTGCCGTCAGAATTAATTAAATTGCTTGAACTCCGTGAAGG
TGATTCAATTGAAATTATCGTTGATGAACCCCGGGTTTTTTCGGTACGCAAGAAACAGAAAGTTGATACTAATTTGCTAG
AGCGTCTGCGTACGTTCCGCGGTAAGCTGCCTGTCAATTTCCATTTTAATCGTGATGAAGCTAATGAGCGCAATTAA