Detailed information of TA system TA076910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2117011..2117710
• Replicon: chromosome
• Accession: NZ_CP021659
• Organism: Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: CCS41_RS10145
• Protein ID: WP_119797536.1
• Coordinates: 2117336..2117710 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: CCS41_RS10140
• Protein ID: WP_119797535.1
• Coordinates: 2117011..2117349 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS41_RS10115	2112917..2114128	+	1212	WP_072550900.1	aspartate/tyrosine/aromatic aminotransferase	-
CCS41_RS10120	2114159..2114719	+	561	WP_072550899.1	conjugative transfer signal peptidase TraF	-
CCS41_RS10130	2115019..2116041	-	1023	WP_119797534.1	IS630 family transposase	-
CCS41_RS10135	2116097..2116819	-	723	Protein_1968	tyrosine-type recombinase/integrase	-
CCS41_RS10140	2117011..2117349	-	339	WP_119797535.1	helix-turn-helix domain-containing protein	Antitoxin
CCS41_RS10145	2117336..2117710	-	375	WP_119797536.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCS41_RS10150	2118138..2118473	-	336	WP_119797537.1	helix-turn-helix domain-containing protein	-
CCS41_RS10155	2118556..2118771	+	216	WP_119797538.1	hypothetical protein	-
CCS41_RS10160	2118759..2118961	+	203	Protein_1973	DNA-binding protein	-
CCS41_RS10165	2118969..2119148	+	180	Protein_1974	hypothetical protein	-
CCS41_RS10175	2119956..2120243	+	288	WP_162860102.1	DUF2724 domain-containing protein	-
CCS41_RS10180	2120185..2120532	+	348	WP_119797054.1	DUF5347 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2116091..2160626	44535

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (16-95)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13780.03 Da
• Isoelectric Point: 10.0568

>T76910 WP_119797536.1 NZ_CP021659:c2117710-2117336 [Candidatus Fukatsuia symbiotica]
MNAKTEKSLVWIGSSKKDLLELPQDIVKSVGYTLHFAQKGLTPPNVKPLSGFHGAGVLEVVENYDGNTYRAICTVKFASV
VFVLHCFQKKSKKGIATPRADLDLIRTRLNTAQQIYEDMKNGKI

Nucleotide

• Length: 375 bp

>T76910 NZ_CP021659:c2117710-2117336 [Candidatus Fukatsuia symbiotica]
ATGAATGCCAAGACTGAAAAATCTTTAGTTTGGATAGGGAGCAGTAAAAAAGACTTGTTGGAACTGCCGCAAGACATTGT
TAAATCTGTCGGTTATACGCTGCATTTTGCCCAAAAAGGCTTAACGCCTCCAAACGTTAAACCATTATCTGGGTTTCATG
GTGCTGGTGTACTTGAAGTCGTAGAAAATTATGATGGTAACACCTATCGGGCTATCTGTACGGTTAAGTTTGCAAGTGTT
GTATTTGTTTTACATTGCTTCCAGAAAAAATCCAAAAAGGGCATAGCTACACCAAGGGCTGATCTTGATCTGATAAGAAC
CCGCCTCAACACAGCCCAACAGATTTATGAGGATATGAAGAATGGAAAGATCTAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12760.77 Da
• Isoelectric Point: 8.9247

>AT76910 WP_119797535.1 NZ_CP021659:c2117349-2117011 [Candidatus Fukatsuia symbiotica]
MERSKEYDFEVGSDNVFSDLNLPNSESLKLKADLAIQIITTIKKMGLNQAEAGKRMHLPQARVSALYNGKFFNMSEKKLM
DCLNRLGYDIEIVVKPSHEFLGRRTLFIPAHS

Nucleotide

• Length: 339 bp

>AT76910 NZ_CP021659:c2117349-2117011 [Candidatus Fukatsuia symbiotica]
ATGGAAAGATCTAAAGAATATGATTTTGAAGTCGGATCAGATAATGTTTTTTCTGATTTAAATTTACCAAACTCAGAAAG
TCTGAAGCTAAAAGCTGACTTAGCTATACAAATTATTACGACCATAAAAAAAATGGGGTTAAATCAGGCCGAAGCAGGTA
AAAGAATGCATTTACCTCAAGCGCGTGTTTCTGCACTTTATAACGGTAAATTCTTCAATATGTCAGAAAAAAAACTGATG
GATTGTTTAAACCGACTCGGTTATGACATTGAAATCGTAGTAAAACCTAGCCATGAATTTTTAGGTCGTAGAACATTATT
TATACCCGCGCATAGCTAA