Detailed information of TA system TA076906

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1108245..1108902
• Replicon: chromosome
• Accession: NZ_CP021659
• Organism: Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CCS41_RS05375
• Protein ID: WP_072550622.1
• Coordinates: 1108492..1108902 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2U8I4G7
• Locus tag: CCS41_RS05370
• Protein ID: WP_072550621.1
• Coordinates: 1108245..1108511 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS41_RS05335	1103281..1103792	-	512	Protein_1050	hypothetical protein	-
CCS41_RS05340	1103825..1104190	+	366	WP_072550348.1	IS630 transposase-related protein	-
CCS41_RS05345	1104177..1104647	+	471	WP_119797310.1	transposase	-
CCS41_RS05355	1104853..1105617	+	765	WP_119797311.1	DDE-type integrase/transposase/recombinase	-
CCS41_RS05360	1106305..1106649	-	345	WP_072550619.1	outer membrane protein assembly factor BamE	-
CCS41_RS05365	1107135..1108127	-	993	WP_119797312.1	tRNA-modifying protein YgfZ	-
CCS41_RS05370	1108245..1108511	+	267	WP_072550621.1	FAD assembly factor SdhE	Antitoxin
CCS41_RS05375	1108492..1108902	+	411	WP_072550622.1	hypothetical protein	Toxin
CCS41_RS05380	1108933..1109646	-	714	WP_072550623.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CCS41_RS05385	1109720..1110805	-	1086	WP_072550624.1	outer membrane protein assembly factor BamC	-
CCS41_RS05390	1110816..1111739	-	924	WP_072550625.1	4-hydroxy-tetrahydrodipicolinate synthase	-
CCS41_RS05395	1112240..1112683	-	444	WP_072550626.1	ferric iron uptake transcriptional regulator	-
CCS41_RS05400	1112816..1113352	-	537	WP_119797728.1	flavodoxin FldA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-78)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15913.53 Da
• Isoelectric Point: 10.0433

>T76906 WP_072550622.1 NZ_CP021659:1108492-1108902 [Candidatus Fukatsuia symbiotica]
VVLWQSEPRISGRSQLFSLLLYIVLILSLLSAPWPVGYQPLGLLLLAAIVFEYIRQQKKRVSSSSIVKFKADNLLEWDQQ
ERYISQPARITRYGVLLALKHSDNKKHQRLWLASDSMTEKEWRTLCQLLRESSDYH

Nucleotide

• Length: 411 bp

>T76906 NZ_CP021659:1108492-1108902 [Candidatus Fukatsuia symbiotica]
GTGGTTCTGTGGCAATCTGAACCACGGATCTCAGGACGCAGCCAGTTGTTTTCGCTGTTGCTGTATATCGTGCTGATATT
ATCGCTTTTATCCGCACCTTGGCCGGTGGGATACCAGCCTCTTGGTTTGCTGCTGCTGGCAGCGATTGTATTTGAGTATA
TCCGCCAGCAGAAAAAAAGGGTTTCTTCTTCGTCTATCGTCAAATTTAAAGCTGATAATTTACTGGAATGGGATCAGCAA
GAACGGTATATCAGTCAACCTGCTCGGATCACACGCTACGGTGTACTGCTTGCGCTAAAACACTCAGATAACAAGAAACA
TCAACGTCTGTGGTTAGCGTCCGACAGTATGACAGAAAAAGAATGGCGTACGCTCTGTCAGTTACTTCGAGAGTCATCCG
ATTACCATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10584.13 Da
• Isoelectric Point: 4.7968

>AT76906 WP_072550621.1 NZ_CP021659:1108245-1108511 [Candidatus Fukatsuia symbiotica]
MNIDNKTRIHWACRRGMRELDLSIMPFFEYEYDTLDDNDKCLFIRLLSSDDPDLFNWLMNYGESPDYELQRMVKLIQMRN
KARGSVAI

Nucleotide

• Length: 267 bp

>AT76906 NZ_CP021659:1108245-1108511 [Candidatus Fukatsuia symbiotica]
ATGAATATCGATAATAAAACGCGTATCCATTGGGCATGCCGTCGTGGGATGCGTGAGCTGGATCTTTCTATTATGCCATT
TTTTGAATACGAGTATGATACGCTCGATGATAATGACAAATGTTTATTTATCCGTTTACTCAGTAGTGACGATCCGGACC
TGTTTAATTGGCTAATGAATTATGGAGAATCACCGGATTACGAATTACAAAGGATGGTCAAACTGATTCAGATGAGAAAT
AAAGCCCGTGGTTCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2U8I4G7