Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 664601..665252 Replicon chromosome
Accession NZ_CP021659
Organism Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CCS41_RS03125 Protein ID WP_119797191.1
Coordinates 664601..665026 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CCS41_RS03130 Protein ID WP_119797192.1
Coordinates 665019..665252 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS41_RS03085 659686..659805 - 120 WP_083429653.1 hypothetical protein -
CCS41_RS16005 659940..660644 + 705 WP_205411479.1 LD-carboxypeptidase -
CCS41_RS16010 660626..661018 + 393 WP_205411509.1 hypothetical protein -
CCS41_RS03095 661193..661303 - 111 Protein_607 IS5/IS1182 family transposase -
CCS41_RS03100 661762..661863 + 102 WP_162859975.1 hypothetical protein -
CCS41_RS03105 661867..662085 + 219 WP_072550915.1 hypothetical protein -
CCS41_RS03110 662088..663110 - 1023 WP_119797190.1 IS630 family transposase -
CCS41_RS03115 663221..664044 - 824 Protein_611 IS5 family transposase -
CCS41_RS03125 664601..665026 - 426 WP_119797191.1 type II toxin-antitoxin system VapC family toxin Toxin
CCS41_RS03130 665019..665252 - 234 WP_119797192.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CCS41_RS03140 665693..665911 - 219 Protein_614 integrase -
CCS41_RS03145 665920..666941 - 1022 Protein_615 IS630 family transposase -
CCS41_RS03150 667001..667639 - 639 Protein_616 integrase -
CCS41_RS03155 667655..668048 - 394 Protein_617 transposase -
CCS41_RS03160 668097..668834 - 738 Protein_618 hypothetical protein -
CCS41_RS03165 669036..670130 - 1095 WP_119797091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(9-54)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15739.51 Da        Isoelectric Point: 9.4871

>T76904 WP_119797191.1 NZ_CP021659:c665026-664601 [Candidatus Fukatsuia symbiotica]
MIKRVYMLDTNICSFIMRKRPTEVIIKLQRCVERKDKIVVSAITYAEMRFGAIGKKASPKHIYLVDEFVKRFDSILPWDV
AAIDATTSVKLELAKLGTPIGGNDAAIAGHALSVGAILVTNNVKEFERVKELTIEDWVSTS

Download         Length: 426 bp

>T76904 NZ_CP021659:c665026-664601 [Candidatus Fukatsuia symbiotica]
ATGATTAAAAGAGTTTATATGCTTGATACCAATATTTGTTCATTCATTATGCGAAAACGTCCCACTGAAGTGATAATCAA
GTTACAACGGTGTGTCGAACGGAAAGATAAAATAGTAGTATCTGCAATAACCTATGCTGAAATGCGGTTCGGTGCTATTG
GTAAGAAGGCGTCCCCCAAACATATTTATCTGGTTGATGAGTTTGTTAAGCGTTTTGATTCGATTCTTCCTTGGGATGTT
GCGGCAATTGATGCAACCACTTCAGTTAAACTTGAACTGGCAAAATTAGGGACTCCAATAGGTGGCAATGATGCAGCCAT
TGCAGGTCATGCTCTTTCTGTTGGTGCCATATTGGTGACAAATAATGTAAAAGAATTTGAACGAGTTAAAGAATTAACAA
TAGAAGATTGGGTGTCTACCAGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9087.31 Da        Isoelectric Point: 4.2687

>AT76904 WP_119797192.1 NZ_CP021659:c665252-665019 [Candidatus Fukatsuia symbiotica]
MRTVSIFNNGKNRAIRLPKDMDFDNITELEIIKDGDSLILRPIRPTWISLIEQEKVVDDDFLSERENIIDEGRFCYD

Download         Length: 234 bp

>AT76904 NZ_CP021659:c665252-665019 [Candidatus Fukatsuia symbiotica]
ATGAGAACAGTATCTATTTTTAACAATGGTAAAAATAGGGCTATTAGATTACCAAAAGATATGGATTTTGACAATATCAC
TGAATTGGAAATCATCAAAGATGGCGACAGCTTAATATTGCGTCCCATACGCCCGACATGGATTTCTCTTATAGAACAAG
AAAAAGTAGTAGATGATGATTTTCTGTCAGAAAGAGAAAATATTATCGATGAGGGGCGTTTTTGTTATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References