Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1031977..1032521 Replicon plasmid unnamed
Accession NZ_CP021653
Organism Ralstonia solanacearum strain RS 488

Toxin (Protein)


Gene name relE Uniprot ID A0A850FHQ1
Locus tag CCY86_RS20105 Protein ID WP_003265047.1
Coordinates 1032246..1032521 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B5SCJ2
Locus tag CCY86_RS20100 Protein ID WP_003265048.1
Coordinates 1031977..1032246 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCY86_RS20075 1027141..1028370 - 1230 WP_003265052.1 efflux RND transporter periplasmic adaptor subunit -
CCY86_RS20080 1028740..1029618 - 879 WP_003265051.1 EamA family transporter -
CCY86_RS20090 1030276..1030659 + 384 WP_003265050.1 hypothetical protein -
CCY86_RS20095 1030702..1031598 - 897 WP_039555871.1 LysR family transcriptional regulator -
CCY86_RS20100 1031977..1032246 + 270 WP_003265048.1 ribbon-helix-helix domain-containing protein Antitoxin
CCY86_RS20105 1032246..1032521 + 276 WP_003265047.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCY86_RS20110 1032635..1033495 - 861 WP_039555861.1 spermidine synthase -
CCY86_RS20115 1033785..1034720 + 936 WP_003265044.1 5-dehydro-4-deoxyglucarate dehydratase -
CCY86_RS20120 1034752..1036338 + 1587 WP_003265043.1 aldehyde dehydrogenase (NADP(+)) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1999547 1999547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10700.46 Da        Isoelectric Point: 9.8951

>T76899 WP_003265047.1 NZ_CP021653:1032246-1032521 [Ralstonia solanacearum]
MELKWTSKALSDVARLYEFLAPVNKPAAARAVQALIKAPTILLTNPRVGEQLFQFEPREVRRILVGQYEMRYALQDETIY
VLRLWHTREDR

Download         Length: 276 bp

>T76899 NZ_CP021653:1032246-1032521 [Ralstonia solanacearum]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGATGTGGCGCGCCTGTATGAATTCCTGGCCCCTGTCAACAAGCCAGC
CGCCGCTCGGGCAGTGCAAGCGCTGATCAAGGCCCCGACCATTTTGCTGACCAACCCGCGCGTTGGCGAACAACTATTTC
AGTTCGAGCCGCGCGAGGTGCGTCGGATTCTGGTCGGCCAGTACGAGATGCGCTACGCACTCCAGGACGAGACGATCTAC
GTGCTGCGGCTGTGGCACACCAGGGAGGATCGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.42 Da        Isoelectric Point: 4.8616

>AT76899 WP_003265048.1 NZ_CP021653:1031977-1032246 [Ralstonia solanacearum]
MPKAETRVLTAHVPVLLAEKVDQLAERLERSRGWIMKQALSAWIGQEEERDRLTHEALADMDAGRVIDHQAVQAWADSLS
TDEPLQVPR

Download         Length: 270 bp

>AT76899 NZ_CP021653:1031977-1032246 [Ralstonia solanacearum]
ATGCCTAAAGCCGAAACACGCGTGCTGACCGCGCACGTTCCCGTTCTCCTTGCCGAGAAAGTTGACCAATTGGCTGAGCG
CCTCGAACGCTCGCGCGGCTGGATCATGAAACAGGCGCTCTCGGCTTGGATCGGCCAGGAGGAAGAGCGCGACCGCTTGA
CCCACGAGGCGCTGGCTGACATGGATGCCGGCCGCGTCATCGACCATCAGGCTGTTCAGGCATGGGCGGATAGCCTGAGC
ACTGACGAACCGCTGCAGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A850FHQ1

Antitoxin

Source ID Structure
AlphaFold DB B5SCJ2

References