Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 16499..17052 Replicon plasmid p3-T1
Accession NZ_CP021651
Organism Acidovorax sp. T1

Toxin (Protein)


Gene name relE Uniprot ID A0A1L5QZG5
Locus tag CCX87_RS20395 Protein ID WP_054471487.1
Coordinates 16759..17052 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6N8S2B8
Locus tag CCX87_RS20390 Protein ID WP_054471486.1
Coordinates 16499..16771 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCX87_RS20365 11754..12368 - 615 WP_000904941.1 recombinase family protein -
CCX87_RS20370 12429..13646 - 1218 WP_003465063.1 TniQ family protein -
CCX87_RS20375 13643..14551 - 909 WP_003465065.1 TniB family NTP-binding protein -
CCX87_RS20380 14554..16233 - 1680 WP_003465068.1 DDE-type integrase/transposase/recombinase -
CCX87_RS20390 16499..16771 + 273 WP_054471486.1 CopG family ribbon-helix-helix protein Antitoxin
CCX87_RS20395 16759..17052 + 294 WP_054471487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCX87_RS21175 17052..17222 + 171 WP_167370944.1 hypothetical protein -
CCX87_RS20400 17219..17593 + 375 WP_061070726.1 hypothetical protein -
CCX87_RS20405 17749..17982 - 234 WP_011997484.1 type I toxin-antitoxin system ptaRNA1 family toxin -
CCX87_RS20410 18046..18303 - 258 WP_061070727.1 hypothetical protein -
CCX87_RS20415 18306..19967 - 1662 WP_061070728.1 P-type conjugative transfer protein TrbL -
CCX87_RS20420 19964..20230 - 267 WP_061070719.1 entry exclusion lipoprotein TrbK -
CCX87_RS20425 20246..21031 - 786 WP_061070720.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..56357 56357
- flank IS/Tn - - 11754..12368 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10811.34 Da        Isoelectric Point: 5.1583

>T76895 WP_054471487.1 NZ_CP021651:16759-17052 [Acidovorax sp. T1]
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVALYRHEPA
DDAVYVLAFRHQKEAGY

Download         Length: 294 bp

>T76895 NZ_CP021651:16759-17052 [Acidovorax sp. T1]
GTGCCACAAGTAATCGTCACCGAAGGCGCGGCGGAAGGCTTGGAACGATGCCGGCGGTTCCTGGCCGTCAAGGCACCGGA
CGCCGCCAGGCGTGCCGGCCAGGCCATCGAGCGGCAATTCCTGCTGCTGGAGACGGCCCCGGACATTGGCCGGCCGTTCC
CTGAAATGCCCGAGCTGCGCGAGCTGGTGATTGCCTTCGGGGATTCCGGCTATGTGGCCCTGTACCGCCACGAACCGGCC
GACGATGCGGTGTATGTTCTGGCCTTCCGGCACCAGAAAGAGGCGGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10563.86 Da        Isoelectric Point: 8.0869

>AT76895 WP_054471486.1 NZ_CP021651:16499-16771 [Acidovorax sp. T1]
MATSLKIDDTLKGRVQHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTN
DERAVPECHK

Download         Length: 273 bp

>AT76895 NZ_CP021651:16499-16771 [Acidovorax sp. T1]
ATGGCAACGTCTCTCAAGATCGACGACACGCTGAAAGGTCGCGTCCAGCACCTCGCCAGCCAGCGCCGCCGCTCGCCCCA
CTGGATCATGCTCGAAGCGATCCAGCAGTACGTCGAGCGCGAAGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCGT
CCTGGGCGGCCTACAAGGAAACCGGCCGCCACCTGACCGGCCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCAAT
GACGAAAGGGCGGTGCCTGAGTGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5QZG5

Antitoxin

Source ID Structure
AlphaFold DB A0A6N8S2B8

References