Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 103116..104643 Replicon plasmid p1-T1
Accession NZ_CP021649
Organism Acidovorax sp. T1

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CCX87_RS19480 Protein ID WP_087748561.1
Coordinates 103366..104643 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CCX87_RS19475 Protein ID WP_086929086.1
Coordinates 103116..103376 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCX87_RS19455 98905..100251 + 1347 WP_086929083.1 replication initiation protein -
CCX87_RS19460 100536..101606 + 1071 WP_157667156.1 site-specific integrase -
CCX87_RS19470 102022..102537 + 516 Protein_91 hypothetical protein -
CCX87_RS19475 103116..103376 + 261 WP_086929086.1 helix-turn-helix transcriptional regulator Antitoxin
CCX87_RS19480 103366..104643 + 1278 WP_087748561.1 type II toxin-antitoxin system HipA family toxin Toxin
CCX87_RS19485 104837..105289 + 453 WP_086929088.1 hypothetical protein -
CCX87_RS19490 106104..107123 + 1020 Protein_95 IS30 family transposase -
CCX87_RS19495 107142..107705 - 564 WP_143218421.1 hypothetical protein -
CCX87_RS21010 108169..108426 - 258 WP_143218422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183061 183061
- flank IS/Tn - - 109269..112196 2927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 46975.04 Da        Isoelectric Point: 6.8698

>T76893 WP_087748561.1 NZ_CP021649:103366-104643 [Acidovorax sp. T1]
MVHELEVWVFADRVGTLALVDGRLNFCYLPDWLSHKDAITLSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAKQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRSDDVQWLSDEEVVAILNELPRRPMLAGQDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKPAIHAVEDSVSNEGFCMALAEAMQLKPAKSKVHKVLDRSFLLVERYDRLIDAQGNRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLVQCFDLLRSATRPSAPQVLRLLDYVIFNALIGNHDAHAKNFSLLYSGKAPVLAPSYD
TLSTAAYPTMTQKMAMKIGSNYKFSEVQARHWEQFAESVGLTKAQAKRRILELAKLLPANARKLQFAPERGFVGNAVVEQ
ISTLIEHCCALTIRRLNVPATESSV

Download         Length: 1278 bp

>T76893 NZ_CP021649:103366-104643 [Acidovorax sp. T1]
ATGGTGCATGAACTGGAAGTCTGGGTTTTTGCAGATCGTGTCGGCACGTTGGCGCTGGTTGATGGTCGACTCAACTTTTG
CTACCTACCCGATTGGCTGTCACACAAGGACGCCATCACCTTGTCTGCCTCGCTGCCCCTGCAAGCGGAGCCGTTCGACG
ATCGCAAAACGCGCCCCTTCTTTGCGGGTCTTCTGCCCGAAGGGCAGATGCGCCGCTTGATTGCGAAACAATTCCAAGTT
TCAGGCCAGAACGACTTTGCACTGCTGGACCACATTGGCGGCGAATGCGCCGGGGCTGTGACGTTCCTGGAGCCGGGGCA
AGCTTTGCCTGTGCCGACCCGTAGCGATGACGTTCAATGGCTGAGCGACGAGGAAGTTGTTGCCATCCTGAATGAATTAC
CGCGCCGCCCCATGTTGGCAGGCCAAGACGGCTTGCGGCTTTCATTGGCAGGTGCCCAGGACAAACTACCGGTGGTGTTT
GACGGTGCCCGCATTGGTCTGCCCCTCAACGGAACGCCTAGCTCGCATATCCTGAAACCGGCCATTCACGCTGTTGAAGA
CAGCGTGAGTAACGAGGGATTCTGCATGGCACTGGCTGAGGCCATGCAGCTCAAGCCAGCGAAATCAAAAGTACACAAGG
TATTGGATCGCTCCTTTCTGCTGGTTGAACGCTACGACCGACTGATTGATGCGCAGGGGAACCGACAACGCCTTCATCAA
GAGGATTTCTGCCAGGCGCTGGGTGTGGTGCCAGAAATGAAATACCAAAATGAAGGTGGTCCGGATCTGGTGCAATGCTT
TGATCTGTTACGCAGTGCGACACGCCCCAGTGCACCGCAGGTTCTGCGACTGCTCGACTATGTGATCTTCAATGCGCTGA
TCGGCAATCATGATGCGCACGCCAAGAATTTCTCACTGCTGTACTCGGGCAAGGCGCCCGTTCTGGCACCGTCTTACGAC
ACGCTCTCGACGGCAGCGTATCCAACAATGACGCAAAAGATGGCGATGAAAATCGGCAGCAACTACAAGTTCAGCGAAGT
CCAGGCGCGTCACTGGGAGCAGTTTGCTGAAAGCGTCGGGCTAACCAAAGCGCAGGCCAAACGGCGAATTCTGGAGCTGG
CAAAATTACTACCAGCGAATGCACGCAAGCTTCAGTTTGCCCCTGAACGAGGTTTTGTGGGGAATGCCGTGGTAGAGCAA
ATCAGTACCTTGATCGAACACTGCTGCGCACTGACGATTCGGCGGCTCAACGTCCCCGCCACCGAATCCTCTGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8987.31 Da        Isoelectric Point: 5.7527

>AT76893 WP_086929086.1 NZ_CP021649:103116-103376 [Acidovorax sp. T1]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVELEAGKPTLRLENVLRVIDALGGEIQLSGLPSTVVDDQCE
GGNHGA

Download         Length: 261 bp

>AT76893 NZ_CP021649:103116-103376 [Acidovorax sp. T1]
ATGACATCCATTCGATCCCCGCAACAACTCGGTGATGCACTGCGTGCCGCACGCAAACAGCTCGGGCTGACACAGCCTCA
GCTGGCTCTGGCGGCTGGGGTAGGGGTGCGCTTCATTGTCGAGCTTGAAGCAGGCAAACCCACCTTGCGACTGGAAAACG
TGCTACGGGTCATTGATGCCCTGGGTGGTGAGATTCAGTTGAGCGGGTTGCCATCAACCGTAGTCGACGATCAATGTGAA
GGTGGCAACCATGGTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References