Detailed information of TA system TA076892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 88165..88874
• Replicon: plasmid p1-T1
• Accession: NZ_CP021649
• Organism: Acidovorax sp. T1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A210VR27
• Locus tag: CCX87_RS19420
• Protein ID: WP_011805136.1
• Coordinates: 88491..88874 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: CCX87_RS19415
• Protein ID: WP_011805135.1
• Coordinates: 88165..88494 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX87_RS19390	83669..85069	+	1401	WP_114655503.1	sodium:proton exchanger	-
CCX87_RS19400	85437..85757	-	321	WP_067513095.1	copper-binding protein	-
CCX87_RS19405	86148..86441	+	294	WP_049756471.1	MerR family DNA-binding protein	-
CCX87_RS19410	86452..88152	+	1701	WP_011805134.1	site-specific integrase	-
CCX87_RS19415	88165..88494	-	330	WP_011805135.1	helix-turn-helix domain-containing protein	Antitoxin
CCX87_RS19420	88491..88874	-	384	WP_011805136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCX87_RS19425	89271..91079	+	1809	WP_086929080.1	site-specific integrase	-
CCX87_RS19430	92015..92683	+	669	WP_086929081.1	AAA family ATPase	-
CCX87_RS19435	92686..93678	+	993	WP_087748586.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..183061	183061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14062.15 Da
• Isoelectric Point: 10.0145

>T76892 WP_011805136.1 NZ_CP021649:c88874-88491 [Acidovorax sp. T1]
MSTQPRKPLKWVGSAKRDLDGMPEDVQDVFGHAIDLAQAGGKHPDAKALSGFGSAAVLEVVEDFRSDTFRAVYTVKFAGW
VYVLHCFQKKSKSGIKTPKEDLDLIKARLKAAVQDFEAWQAKQGVKR

Nucleotide

• Length: 384 bp

>T76892 NZ_CP021649:c88874-88491 [Acidovorax sp. T1]
ATGTCCACCCAGCCGCGCAAACCGCTCAAATGGGTCGGCTCGGCCAAGCGGGATCTGGACGGAATGCCCGAGGACGTCCA
AGACGTGTTCGGCCATGCGATCGACCTGGCGCAAGCCGGTGGCAAGCACCCGGACGCCAAGGCGCTGAGCGGGTTTGGTT
CCGCCGCGGTTTTGGAAGTGGTCGAGGATTTCCGGAGCGACACGTTCCGGGCGGTCTACACGGTCAAGTTCGCGGGCTGG
GTCTATGTGCTGCACTGTTTTCAGAAGAAGTCCAAGAGCGGCATCAAGACGCCGAAGGAGGACCTGGACCTGATCAAGGC
ACGGCTGAAGGCTGCGGTGCAGGATTTTGAGGCTTGGCAAGCAAAGCAAGGAGTAAAGCGATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11929.73 Da
• Isoelectric Point: 10.5281

>AT76892 WP_011805135.1 NZ_CP021649:c88494-88165 [Acidovorax sp. T1]
MSQNSHITIEEGSTNVYADLGYADAAEMQRKSQLAAEIARAIKARRLTQQGAAALLEIDQSKISRITRGQFRGVSEAKLL
ELVAKLGHDVKIVVGPVRRRAGKIELQFA

Nucleotide

• Length: 330 bp

>AT76892 NZ_CP021649:c88494-88165 [Acidovorax sp. T1]
ATGAGCCAGAACAGCCACATCACCATCGAAGAAGGCAGCACCAACGTCTACGCGGACCTGGGCTATGCCGACGCTGCGGA
AATGCAGCGCAAGTCGCAGCTCGCGGCTGAGATTGCCCGCGCCATCAAGGCGCGACGCCTGACGCAACAGGGAGCCGCCG
CGCTGCTGGAAATCGATCAGTCCAAGATCTCCCGCATCACGCGCGGCCAGTTTCGCGGGGTCAGCGAGGCGAAGCTGCTG
GAACTGGTGGCCAAGCTGGGGCATGACGTGAAGATCGTGGTCGGTCCAGTACGGCGGCGTGCCGGTAAGATCGAGCTGCA
GTTCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A210VR27