Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 60731..61404 Replicon plasmid p1-T1
Accession NZ_CP021649
Organism Acidovorax sp. T1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCX87_RS19285 Protein ID WP_087748543.1
Coordinates 60731..61153 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CCX87_RS19290 Protein ID WP_087748584.1
Coordinates 61150..61404 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCX87_RS19280 57835..60633 - 2799 WP_087748542.1 class I SAM-dependent DNA methyltransferase -
CCX87_RS19285 60731..61153 - 423 WP_087748543.1 type II toxin-antitoxin system VapC family toxin Toxin
CCX87_RS19290 61150..61404 - 255 WP_087748584.1 plasmid stabilization protein Antitoxin
CCX87_RS19295 61501..62487 - 987 WP_157667154.1 MobA/MobL family protein -
CCX87_RS19300 62706..63020 + 315 WP_087748545.1 hypothetical protein -
CCX87_RS19305 63089..64510 - 1422 WP_087748546.1 AAA family ATPase -
CCX87_RS19310 64833..65159 - 327 WP_087748547.1 helix-turn-helix domain-containing protein -
CCX87_RS19315 65298..65570 + 273 WP_087748548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183061 183061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14831.26 Da        Isoelectric Point: 5.8426

>T76891 WP_087748543.1 NZ_CP021649:c61153-60731 [Acidovorax sp. T1]
MILLDTNVMSEPLRHTPEPRVIEWIDAQAMETLFLSAITVAELRAGVALLPAGKRRAGLQENLEKRVLPLFAGRVLPFDL
ACTQAYAALMAKARSAGLAVATADGYIAAIAAANGFAVATRDTSPFEAAGVTVINPWAQV

Download         Length: 423 bp

>T76891 NZ_CP021649:c61153-60731 [Acidovorax sp. T1]
ATGATCCTGCTCGACACCAATGTGATGTCGGAGCCGCTCCGGCACACTCCCGAGCCGCGGGTGATCGAGTGGATCGACGC
CCAAGCCATGGAGACCTTGTTCCTCTCCGCCATCACGGTGGCGGAACTGCGAGCGGGTGTCGCCCTGCTGCCGGCCGGCA
AGCGGCGCGCAGGCCTGCAAGAGAACTTGGAAAAGCGCGTGCTGCCATTGTTCGCCGGCCGCGTGCTGCCCTTTGACTTG
GCCTGCACCCAGGCCTATGCGGCGCTGATGGCGAAGGCCCGCAGCGCTGGCTTGGCCGTTGCCACGGCTGATGGCTACAT
CGCAGCGATCGCCGCGGCCAACGGTTTCGCTGTCGCGACCCGAGACACCAGCCCGTTCGAGGCGGCGGGCGTCACCGTCA
TCAACCCATGGGCTCAGGTGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9406.79 Da        Isoelectric Point: 7.2063

>AT76891 WP_087748584.1 NZ_CP021649:c61404-61150 [Acidovorax sp. T1]
MAMLTVRNLSEEVHRALRVRAAQHGQSMEAEVREILESAISPKGRVKLGSLLADMGRQAKLSDEEFAVFEQVRDKTPARP
VSFE

Download         Length: 255 bp

>AT76891 NZ_CP021649:c61404-61150 [Acidovorax sp. T1]
ATGGCCATGCTGACAGTTCGCAACCTTTCCGAGGAAGTGCACCGTGCTCTGCGCGTCCGTGCTGCCCAGCACGGCCAGAG
CATGGAGGCCGAGGTGCGCGAGATTTTGGAGTCAGCGATCAGCCCCAAGGGGCGCGTGAAGCTGGGTTCTCTCCTGGCCG
ACATGGGCCGTCAAGCCAAGCTGAGCGATGAAGAATTCGCGGTGTTCGAGCAGGTGCGCGACAAGACGCCTGCACGCCCG
GTGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References