Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4049157..4049800 Replicon chromosome
Accession NZ_CP021648
Organism Acidovorax sp. T1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCX87_RS18760 Protein ID WP_087748050.1
Coordinates 4049157..4049567 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CCX87_RS18765 Protein ID WP_087748051.1
Coordinates 4049567..4049800 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCX87_RS18725 4045068..4046465 + 1398 WP_087748044.1 Fic family protein -
CCX87_RS18730 4046513..4046914 - 402 WP_087748045.1 type II toxin-antitoxin system VapC family toxin -
CCX87_RS18735 4046911..4047144 - 234 WP_087748046.1 antitoxin -
CCX87_RS18740 4047244..4047474 - 231 Protein_3712 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CCX87_RS18745 4047471..4048091 - 621 WP_087748047.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
CCX87_RS18750 4048279..4048545 - 267 WP_087748048.1 BrnA antitoxin family protein -
CCX87_RS18755 4048529..4048828 - 300 WP_087748049.1 BrnT family toxin -
CCX87_RS18760 4049157..4049567 - 411 WP_087748050.1 type II toxin-antitoxin system VapC family toxin Toxin
CCX87_RS18765 4049567..4049800 - 234 WP_087748051.1 antitoxin Antitoxin
CCX87_RS18770 4049870..4050661 - 792 WP_087748052.1 3',5'-cyclic-nucleotide phosphodiesterase -
CCX87_RS18775 4050760..4051419 - 660 WP_087748053.1 FHA domain-containing protein -
CCX87_RS18780 4051463..4052251 - 789 WP_087748054.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
CCX87_RS18785 4052406..4053491 - 1086 WP_087748270.1 IS630 family transposase -
CCX87_RS18790 4053872..4054048 - 177 Protein_3722 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14895.28 Da        Isoelectric Point: 8.0901

>T76890 WP_087748050.1 NZ_CP021648:c4049567-4049157 [Acidovorax sp. T1]
MLRYLLDTNIVIYVVKRRPVEVMPIFNANAGRMAISAITLSELMHGAEKSSKVSENLAVIEDFCSRLEVLPYGSKAAQHY
GAIRAGLEKIGQPIGVNDLHIAAHARSEGLVMVTHNVGEFARVPALQVENWVGTNK

Download         Length: 411 bp

>T76890 NZ_CP021648:c4049567-4049157 [Acidovorax sp. T1]
ATGCTGCGCTACCTGCTCGACACCAACATCGTCATCTACGTTGTGAAGCGCCGCCCCGTCGAGGTCATGCCGATCTTTAA
CGCCAACGCCGGCCGCATGGCCATATCGGCCATCACCTTGTCGGAGCTGATGCACGGCGCCGAAAAAAGCAGCAAGGTCA
GCGAAAACCTGGCGGTTATCGAAGACTTTTGCAGCCGCCTTGAAGTGCTGCCCTACGGCAGCAAGGCGGCCCAGCACTAC
GGCGCCATCCGCGCCGGGCTGGAAAAAATCGGCCAGCCCATTGGAGTGAACGACCTGCACATAGCGGCCCATGCGCGCAG
CGAAGGGCTCGTCATGGTGACCCACAACGTGGGCGAGTTCGCCAGGGTGCCCGCCCTGCAAGTGGAAAACTGGGTCGGCA
CGAACAAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 7.0118

>AT76890 WP_087748051.1 NZ_CP021648:c4049800-4049567 [Acidovorax sp. T1]
MTISTVFINNRTQAVRIPIDLRLPDGVRKVEVRAKGNERIISPVGQTWDSFFLNGPAVSDDFMPERASQHQAERESL

Download         Length: 234 bp

>AT76890 NZ_CP021648:c4049800-4049567 [Acidovorax sp. T1]
ATGACCATCAGCACCGTCTTCATCAACAACCGCACGCAAGCCGTCCGCATCCCCATCGACCTGCGCCTGCCCGACGGCGT
GCGCAAAGTCGAAGTGCGGGCCAAAGGCAACGAGCGCATCATTTCCCCCGTGGGGCAGACATGGGACAGCTTCTTTCTGA
ACGGCCCTGCAGTGAGCGACGACTTCATGCCAGAGCGCGCCAGCCAGCACCAGGCAGAGCGGGAATCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References