Detailed information of TA system TA076889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4046513..4047144
• Replicon: chromosome
• Accession: NZ_CP021648
• Organism: Acidovorax sp. T1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCX87_RS18730
• Protein ID: WP_087748045.1
• Coordinates: 4046513..4046914 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CCX87_RS18735
• Protein ID: WP_087748046.1
• Coordinates: 4046911..4047144 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX87_RS18705	4042088..4042381	-	294	WP_087748041.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CCX87_RS18710	4042381..4042656	-	276	WP_087748042.1	type II toxin-antitoxin system ParD family antitoxin	-
CCX87_RS18715	4042986..4043786	-	801	WP_087748504.1	hypothetical protein	-
CCX87_RS18720	4043915..4044457	-	543	WP_087748043.1	pilin	-
CCX87_RS18725	4045068..4046465	+	1398	WP_087748044.1	Fic family protein	-
CCX87_RS18730	4046513..4046914	-	402	WP_087748045.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCX87_RS18735	4046911..4047144	-	234	WP_087748046.1	antitoxin	Antitoxin
CCX87_RS18740	4047244..4047474	-	231	Protein_3712	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
CCX87_RS18745	4047471..4048091	-	621	WP_087748047.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
CCX87_RS18750	4048279..4048545	-	267	WP_087748048.1	BrnA antitoxin family protein	-
CCX87_RS18755	4048529..4048828	-	300	WP_087748049.1	BrnT family toxin	-
CCX87_RS18760	4049157..4049567	-	411	WP_087748050.1	type II toxin-antitoxin system VapC family toxin	-
CCX87_RS18765	4049567..4049800	-	234	WP_087748051.1	antitoxin	-
CCX87_RS18770	4049870..4050661	-	792	WP_087748052.1	3',5'-cyclic-nucleotide phosphodiesterase	-
CCX87_RS18775	4050760..4051419	-	660	WP_087748053.1	FHA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14764.00 Da
• Isoelectric Point: 5.1354

>T76889 WP_087748045.1 NZ_CP021648:c4046914-4046513 [Acidovorax sp. T1]
MILLDTNICIYIINARPPEVLARFRQYRLGDVGLCSVVAAELAYGVAKSGSARNRAALEMFLAPLEILPFDTNAVWAYGD
LRANLERQGQPIDALDTMIAAHALSLDAPLVTHNTREFERVPGLRLENWVQQS

Nucleotide

• Length: 402 bp

>T76889 NZ_CP021648:c4046914-4046513 [Acidovorax sp. T1]
ATGATTCTGCTGGACACCAACATTTGCATCTACATCATCAACGCCAGGCCACCCGAAGTGCTGGCGCGGTTTCGCCAATA
CCGCCTGGGCGACGTGGGCCTGTGCAGCGTGGTGGCGGCAGAGCTGGCCTACGGCGTGGCCAAAAGCGGCTCGGCGCGCA
ACAGGGCCGCACTGGAGATGTTTTTGGCGCCGCTGGAAATACTGCCCTTCGACACCAACGCGGTCTGGGCTTATGGCGAC
TTGCGCGCCAACCTGGAGCGCCAAGGCCAACCCATCGATGCCCTAGACACCATGATCGCCGCCCACGCACTCAGCCTGGA
CGCGCCCCTGGTCACGCACAACACACGCGAGTTCGAGCGGGTGCCCGGCCTGCGGCTGGAAAACTGGGTGCAGCAGTCAT
AG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8580.79 Da
• Isoelectric Point: 5.7633

>AT76889 WP_087748046.1 NZ_CP021648:c4047144-4046911 [Acidovorax sp. T1]
METARLFQSGRSQAVRLPKEFRFTGTDVGVRHFGNGVLLLPLDNPWDTLEAALSAFEPGFVLAREQPPQQVRPEICA

Nucleotide

• Length: 234 bp

>AT76889 NZ_CP021648:c4047144-4046911 [Acidovorax sp. T1]
ATGGAAACCGCCCGTCTCTTTCAATCGGGTCGCAGCCAAGCGGTCCGGTTGCCCAAGGAATTTCGTTTCACAGGGACCGA
TGTCGGGGTTCGACACTTCGGCAACGGCGTGCTGCTGCTGCCGCTGGACAACCCTTGGGACACCCTCGAAGCCGCCCTGT
CGGCTTTCGAGCCCGGCTTTGTGCTTGCGCGCGAACAGCCGCCACAGCAGGTGCGCCCCGAGATTTGCGCATGA