Detailed information of TA system TA076888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3626302..3627344
• Replicon: chromosome
• Accession: NZ_CP021648
• Organism: Acidovorax sp. T1

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CCX87_RS16880
• Protein ID: WP_003050248.1
• Coordinates: 3626302..3626877 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: I3TV68
• Locus tag: CCX87_RS16885
• Protein ID: WP_003050245.1
• Coordinates: 3626874..3627344 (-)
• Length: 157 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX87_RS16855	3622742..3623467	-	726	WP_003050273.1	CBASS effector endonuclease NucC	-
CCX87_RS16860	3623504..3624406	-	903	WP_003050264.1	nucleotidyltransferase domain-containing protein	-
CCX87_RS16865	3624406..3624906	-	501	WP_003050262.1	hypothetical protein	-
CCX87_RS16870	3624903..3625373	-	471	WP_003050260.1	hypothetical protein	-
CCX87_RS16875	3625370..3626284	-	915	WP_003050256.1	AAA family ATPase	-
CCX87_RS16880	3626302..3626877	-	576	WP_003050248.1	PIN domain-containing protein	Toxin
CCX87_RS16885	3626874..3627344	-	471	WP_003050245.1	helix-turn-helix domain-containing protein	Antitoxin
CCX87_RS16890	3627548..3627931	+	384	WP_003050229.1	RAQPRD family integrative conjugative element protein	-
CCX87_RS16895	3627928..3628161	+	234	WP_003050225.1	TIGR03758 family integrating conjugative element protein	-
CCX87_RS16900	3628178..3628537	+	360	WP_020307818.1	TIGR03745 family integrating conjugative element membrane protein	-
CCX87_RS16905	3628549..3628947	+	399	WP_003050133.1	TIGR03750 family conjugal transfer protein	-
CCX87_RS16910	3628944..3629636	+	693	WP_003050116.1	TIGR03746 family integrating conjugative element protein	-
CCX87_RS16915	3629633..3630544	+	912	WP_003050114.1	TIGR03749 family integrating conjugative element protein	-
CCX87_RS16920	3630534..3631952	+	1419	WP_003050111.1	TIGR03752 family integrating conjugative element protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3429745..3647426	217681

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• Helix-turn-helix domain, group 17 (85-133)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21630.76 Da
• Isoelectric Point: 5.6130

>T76888 WP_003050248.1 NZ_CP021648:c3626877-3626302 [Acidovorax sp. T1]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Nucleotide

• Length: 576 bp

>T76888 NZ_CP021648:c3626877-3626302 [Acidovorax sp. T1]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin

Protein

• Length: 157 a.a.
• Molecular weight: 17245.62 Da
• Isoelectric Point: 6.3803

>AT76888 WP_003050245.1 NZ_CP021648:c3627344-3626874 [Acidovorax sp. T1]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Nucleotide

• Length: 471 bp

>AT76888 NZ_CP021648:c3627344-3626874 [Acidovorax sp. T1]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCGTTGCGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Structures

Antitoxin

• AlphaFold DB: I3TV68