Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1941971..1943658 Replicon chromosome
Accession NZ_CP021644
Organism Glaesserella parasuis 29755

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B4U42_RS10090 Protein ID WP_005713143.1
Coordinates 1942315..1943658 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B4U42_RS10085 Protein ID WP_005713145.1
Coordinates 1941971..1942315 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4U42_RS10065 1938039..1938989 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
B4U42_RS10070 1939017..1939862 - 846 WP_005713151.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
B4U42_RS10075 1939864..1940496 - 633 WP_005713149.1 lipoprotein insertase outer membrane protein LolB -
B4U42_RS10080 1940617..1941942 - 1326 WP_005713147.1 ATP-dependent RNA helicase SrmB -
B4U42_RS10085 1941971..1942315 - 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
B4U42_RS10090 1942315..1943658 - 1344 WP_005713143.1 type II toxin-antitoxin system HipA family toxin Toxin
B4U42_RS10095 1943773..1944210 - 438 WP_005713142.1 ribosomal protein S18-alanine N-acetyltransferase -
B4U42_RS10100 1944452..1944697 - 246 WP_005713138.1 M23 family metallopeptidase -
B4U42_RS10105 1944894..1945307 - 414 WP_005713136.1 DNA polymerase III subunit psi -
B4U42_RS10110 1945390..1946331 + 942 WP_005713135.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
B4U42_RS10115 1946481..1948658 + 2178 WP_005713133.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51066.07 Da        Isoelectric Point: 5.0229

>T76881 WP_005713143.1 NZ_CP021644:c1943658-1942315 [Glaesserella parasuis 29755]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T76881 NZ_CP021644:c1943658-1942315 [Glaesserella parasuis 29755]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ATCCTGTGGAGTTTTTCCCATACCGTAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTTCCTTCTGGAGCAAGT
CGGCGTTATTGGTTGCAAAAACTTGATATTGCTCATTTGCCGACAGCTCAACAAAACTATTTGTTATTAAAACAAGGTAC
GATTGCACCTGTCGGGCATTTACGAGTGAAGCAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTGGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGAAAACGCAGTGCAATAGATTGCGACATATTGAGAGCTGAAT
TTCACTATTACCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGCGGTTGGAAGAGGGCGAACGT
TACCCGTCGTTATGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCTAAAATTGAAA
CCTCTCATTTGGTTGAAACAGGAATGTTTTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGACGAAATACGGCTTTCTTACGCAATCAAAATCGTATCTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCAGATCCTGAAGGTATTCCTCGCACGACAATGTGGGATAGTAAAGGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGACTTAAAGCACGTTTAGAAGCAAGAGGCGTTCCAACGGCAATTTTGAC
GTACCCCTCAATCAGCTTGGACTATTTACCTGAAAAATTAAAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT76881 WP_005713145.1 NZ_CP021644:c1942315-1941971 [Glaesserella parasuis 29755]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT76881 NZ_CP021644:c1942315-1941971 [Glaesserella parasuis 29755]
ATGGAAGAGATCAAACAGGCTAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGCGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGCAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTTGGCGTTGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAACGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References