Detailed information of TA system TA076876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1015508..1016121
• Replicon: chromosome
• Accession: NZ_CP021644
• Organism: Glaesserella parasuis 29755

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B4U42_RS05450
• Protein ID: WP_200859958.1
• Coordinates: 1015954..1016121 (-)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1T0AB61
• Locus tag: B4U42_RS05445
• Protein ID: WP_005714429.1
• Coordinates: 1015508..1015915 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4U42_RS05400	1010648..1011301	-	654	WP_005714960.1	LexA family transcriptional regulator	-
B4U42_RS05405	1011437..1011643	+	207	WP_005714958.1	helix-turn-helix transcriptional regulator	-
B4U42_RS05410	1011664..1011939	+	276	WP_020997037.1	bacteriophage CII family protein	-
B4U42_RS05415	1011984..1012670	+	687	WP_035703224.1	phage antirepressor KilAC domain-containing protein	-
B4U42_RS05420	1012667..1013491	+	825	WP_020997035.1	replication protein	-
B4U42_RS05425	1013491..1014162	+	672	WP_020997224.1	replication P family protein	-
B4U42_RS05430	1014163..1014723	+	561	WP_005714434.1	N-6-adenine methyltransferase	-
B4U42_RS05440	1015025..1015474	+	450	WP_112065008.1	recombination protein NinB	-
B4U42_RS05445	1015508..1015915	-	408	WP_005714429.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B4U42_RS05450	1015954..1016121	-	168	WP_200859958.1	type II toxin-antitoxin system HicA family toxin	Toxin
B4U42_RS05455	1016227..1016517	+	291	WP_005714426.1	DUF1364 domain-containing protein	-
B4U42_RS05460	1016514..1016918	+	405	WP_005714425.1	RusA family crossover junction endodeoxyribonuclease	-
B4U42_RS05465	1016915..1017292	+	378	WP_005714424.1	antitermination protein	-
B4U42_RS05470	1017301..1017486	-	186	WP_005714422.1	hypothetical protein	-
B4U42_RS05475	1017869..1018327	+	459	WP_005714420.1	hypothetical protein	-
B4U42_RS05480	1018414..1018611	-	198	WP_005714419.1	hypothetical protein	-
B4U42_RS05485	1018656..1019483	+	828	WP_005714418.1	phage antirepressor N-terminal domain-containing protein	-
B4U42_RS12380	1019770..1019928	+	159	WP_005714415.1	hypothetical protein	-
B4U42_RS05490	1019975..1020250	+	276	WP_012621834.1	hypothetical protein	-
B4U42_RS05495	1020225..1020770	+	546	WP_020996993.1	lysozyme	-
B4U42_RS05500	1020743..1021087	+	345	WP_040978490.1	DUF2570 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	947234..1043458	96224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-55)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6272.42 Da
• Isoelectric Point: 11.0319

>T76876 WP_200859958.1 NZ_CP021644:c1016121-1015954 [Glaesserella parasuis 29755]
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL

Nucleotide

• Length: 168 bp

>T76876 NZ_CP021644:c1016121-1015954 [Glaesserella parasuis 29755]
ATGATAAAACTTCTCAAAAAGAACGGTTGGGAGCTAGATAGCATAGTCGGTAGCCACCACCACTTTGAGAAGAAAAATCA
AAAGGGAGCAGGCAAAGTGACTGTTCCCCACCCGAGAAAAGACTTAGGCTTTCTCGAAAAGAAAATCAGAAAACAAGCGG
GGCTGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14890.91 Da
• Isoelectric Point: 4.6143

>AT76876 WP_005714429.1 NZ_CP021644:c1015915-1015508 [Glaesserella parasuis 29755]
MLYPLIFEQVSDGYVVAVPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 408 bp

>AT76876 NZ_CP021644:c1015915-1015508 [Glaesserella parasuis 29755]
ATGTTATACCCACTCATTTTTGAACAAGTTTCCGACGGCTATGTCGTTGCTGTCCCAGATATTGACGGCTGTTATTCTGC
TGGAGATACCCTAGAAGAAACTTATAGCAACGTAAAACAAGCTATAGCACTTCATCTCGAATCTGTCGTCAAAGATGGGG
GAGAAATTCCAACGCCTACCGCTATCGAAAACCACAAAAACGACCCTGATTTAGACGGTCATAACGTATTTTTCGGTGTG
GTTGATGTCGATTTATCCCACCTAATGGGCAAAGCAGAGAAAATCAACATCACCCTCCCTAGCTATCTCATCAAACGCAT
TGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAATCTTAA
CCGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T0AB61