Detailed information of TA system TA076875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 960755..961377
• Replicon: chromosome
• Accession: NZ_CP021644
• Organism: Glaesserella parasuis 29755

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A836YYE8
• Locus tag: B4U42_RS05050
• Protein ID: WP_005715063.1
• Coordinates: 961195..961377 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A837B0B6
• Locus tag: B4U42_RS05045
• Protein ID: WP_005715065.1
• Coordinates: 960755..961168 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4U42_RS05015	956658..957341	-	684	WP_005714533.1	helix-turn-helix transcriptional regulator	-
B4U42_RS05020	957472..957672	+	201	WP_005714531.1	helix-turn-helix domain-containing protein	-
B4U42_RS12365	957693..957950	+	258	Protein_918	hypothetical protein	-
B4U42_RS05025	958008..958733	+	726	WP_016527921.1	Rha family transcriptional regulator	-
B4U42_RS05030	958730..959560	+	831	WP_020997223.1	hypothetical protein	-
B4U42_RS05035	959560..960231	+	672	WP_005715017.1	replication protein P	-
B4U42_RS05040	960293..960721	+	429	WP_005715214.1	recombination protein NinB	-
B4U42_RS05045	960755..961168	-	414	WP_005715065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B4U42_RS05050	961195..961377	-	183	WP_005715063.1	type II toxin-antitoxin system HicA family toxin	Toxin
B4U42_RS05055	961625..962194	+	570	WP_035703519.1	recombination protein NinG	-
B4U42_RS05060	962191..962568	+	378	WP_020997228.1	sigma-70 family RNA polymerase sigma factor	-
B4U42_RS05065	962625..963833	-	1209	WP_112065003.1	IS256 family transposase	-
B4U42_RS05070	963900..964118	-	219	WP_005714782.1	hypothetical protein	-
B4U42_RS12370	964415..964591	+	177	WP_005714781.1	hypothetical protein	-
B4U42_RS05075	964973..965536	-	564	WP_005714778.1	hypothetical protein	-
B4U42_RS05080	965650..965925	+	276	WP_010786311.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	947234..1043458	96224
	-	flank	IS/Tn	-	-	962625..963833	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6678.80 Da
• Isoelectric Point: 10.6602

>T76875 WP_005715063.1 NZ_CP021644:c961377-961195 [Glaesserella parasuis 29755]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Nucleotide

• Length: 183 bp

>T76875 NZ_CP021644:c961377-961195 [Glaesserella parasuis 29755]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCGAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15401.47 Da
• Isoelectric Point: 4.3988

>AT76875 WP_005715065.1 NZ_CP021644:c961168-960755 [Glaesserella parasuis 29755]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 414 bp

>AT76875 NZ_CP021644:c961168-960755 [Glaesserella parasuis 29755]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGATATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTGTTCCACCTTGAAGGCTTAGTTGAAG
ATGGAGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTTTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Structures

Toxin

• AlphaFold DB: A0A836YYE8

Antitoxin

• AlphaFold DB: A0A837B0B6