Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 880498..881275 Replicon chromosome
Accession NZ_CP021644
Organism Glaesserella parasuis 29755

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag B4U42_RS04620 Protein ID WP_005710654.1
Coordinates 880498..880998 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag B4U42_RS04625 Protein ID WP_005710653.1
Coordinates 880988..881275 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4U42_RS04585 875623..875778 - 156 WP_005710668.1 YoaH family protein -
B4U42_RS04590 875796..876524 - 729 WP_005710666.1 tRNA pseudouridine(65) synthase TruC -
B4U42_RS04595 876521..876835 - 315 WP_005710664.1 YqcC family protein -
B4U42_RS04600 876877..877791 - 915 WP_005710662.1 N-acetylmuramic acid 6-phosphate etherase -
B4U42_RS04605 877803..878918 - 1116 WP_005710660.1 anhydro-N-acetylmuramic acid kinase -
B4U42_RS04610 879073..879408 - 336 WP_005710658.1 outer membrane protein assembly factor BamE -
B4U42_RS04615 879469..880470 - 1002 WP_005710656.1 nucleoid-associated protein YejK -
B4U42_RS04620 880498..880998 - 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
B4U42_RS04625 880988..881275 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
B4U42_RS04630 881421..881810 + 390 WP_005710651.1 RidA family protein -
B4U42_RS04635 881814..882551 + 738 WP_005710648.1 peptidoglycan editing factor PgeF -
B4U42_RS04640 882726..884303 + 1578 WP_005710646.1 FAD-binding protein -
B4U42_RS04645 884408..884908 + 501 WP_021109667.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T76874 WP_005710654.1 NZ_CP021644:c880998-880498 [Glaesserella parasuis 29755]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T76874 NZ_CP021644:c880998-880498 [Glaesserella parasuis 29755]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT76874 WP_005710653.1 NZ_CP021644:c881275-880988 [Glaesserella parasuis 29755]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT76874 NZ_CP021644:c881275-880988 [Glaesserella parasuis 29755]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References