Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 613446..613985 Replicon chromosome
Accession NZ_CP021644
Organism Glaesserella parasuis 29755

Toxin (Protein)


Gene name relE Uniprot ID A0A6I5WQI8
Locus tag B4U42_RS03270 Protein ID WP_005714578.1
Coordinates 613716..613985 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B8F4J9
Locus tag B4U42_RS03265 Protein ID WP_005714576.1
Coordinates 613446..613712 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4U42_RS03225 609337..610323 + 987 WP_005714908.1 IS110 family transposase -
B4U42_RS03230 610381..610707 + 327 WP_005714561.1 DUF2190 family protein -
B4U42_RS03235 610700..611005 + 306 WP_005714563.1 phage tail protein -
B4U42_RS03240 611009..611542 + 534 WP_005714565.1 phage tail protein -
B4U42_RS03245 611542..611961 + 420 WP_005714567.1 phage tail protein -
B4U42_RS03250 611964..612629 + 666 WP_005714568.1 hypothetical protein -
B4U42_RS03255 612703..613104 + 402 WP_005714571.1 hypothetical protein -
B4U42_RS03260 613149..613376 + 228 WP_005714573.1 DUF4035 domain-containing protein -
B4U42_RS03265 613446..613712 + 267 WP_005714576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B4U42_RS03270 613716..613985 + 270 WP_005714578.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
B4U42_RS03275 614131..615339 - 1209 WP_016527735.1 IS256 family transposase -
B4U42_RS12235 615443..615658 + 216 WP_035498906.1 hypothetical protein -
B4U42_RS03280 615861..616136 + 276 WP_005714514.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 586516..627977 41461
- flank IS/Tn - - 614131..615339 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-80)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.03 Da        Isoelectric Point: 6.8591

>T76873 WP_005714578.1 NZ_CP021644:613716-613985 [Glaesserella parasuis 29755]
MLQLSPTNAYKRDFKKIASELMSSAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Download         Length: 270 bp

>T76873 NZ_CP021644:613716-613985 [Glaesserella parasuis 29755]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGTCTAGTGCTGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9945.38 Da        Isoelectric Point: 5.0366

>AT76873 WP_005714576.1 NZ_CP021644:613446-613712 [Glaesserella parasuis 29755]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Download         Length: 267 bp

>AT76873 NZ_CP021644:613446-613712 [Glaesserella parasuis 29755]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAAACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAAAATGAAGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5WQI8

Antitoxin

Source ID Structure
AlphaFold DB B8F4J9

References