Detailed information of TA system TA076872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 257204..258753
• Replicon: chromosome
• Accession: NZ_CP021644
• Organism: Glaesserella parasuis 29755

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: B4U42_RS01345
• Protein ID: WP_005713286.1
• Coordinates: 257437..258753 (+)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A836YYU2
• Locus tag: B4U42_RS01340
• Protein ID: WP_005713287.1
• Coordinates: 257204..257443 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4U42_RS01315	253028..253282	+	255	WP_005713300.1	alpha/beta hydrolase	-
B4U42_RS01320	253408..253986	-	579	WP_005713298.1	transcription termination/antitermination protein NusG	-
B4U42_RS01325	253988..254398	-	411	WP_005713295.1	preprotein translocase subunit SecE	-
B4U42_RS01330	254653..256098	-	1446	WP_005713291.1	metalloprotease TldD	-
B4U42_RS01335	256229..257056	+	828	WP_005713289.1	alpha/beta hydrolase	-
B4U42_RS01340	257204..257443	+	240	WP_005713287.1	helix-turn-helix domain-containing protein	Antitoxin
B4U42_RS01345	257437..258753	+	1317	WP_005713286.1	type II toxin-antitoxin system HipA family toxin	Toxin
B4U42_RS01350	258926..259900	-	975	WP_204355917.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
B4U42_RS12325	259908..260144	-	237	WP_021116421.1	GntR family transcriptional regulator	-
B4U42_RS01360	260550..261536	+	987	WP_005714908.1	IS110 family transposase	-
B4U42_RS01365	261640..261963	-	324	Protein_243	LysR family transcriptional regulator	-
B4U42_RS01370	261927..262523	+	597	Protein_244	disulfide bond formation protein DsbA	-
B4U42_RS01375	262613..263206	+	594	WP_005714214.1	sugar O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-404)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50023.36 Da
• Isoelectric Point: 7.9228

>T76872 WP_005713286.1 NZ_CP021644:257437-258753 [Glaesserella parasuis 29755]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMAKILQSYQYNVPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNPNDRRRFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T76872 NZ_CP021644:257437-258753 [Glaesserella parasuis 29755]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCCTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGGCGAAAATTCTACAAAGTT
ATCAATACAATGTCCCACTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCTGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATCCCAACGATCGCC
GTCGATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACATGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGCACGCAAAAAGGAAAAAAATGGCATTGGAGTAAAATTTATGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9068.48 Da
• Isoelectric Point: 9.7687

>AT76872 WP_005713287.1 NZ_CP021644:257204-257443 [Glaesserella parasuis 29755]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIHPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT76872 NZ_CP021644:257204-257443 [Glaesserella parasuis 29755]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TTAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCACCCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A836YYU2