Detailed information of TA system TA076871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 367010..367538
• Replicon: chromosome
• Accession: NZ_CP021642
• Organism: Campylobacter concisus strain P2CDO4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2FZT6
• Locus tag: CCS77_RS01845
• Protein ID: WP_021084979.1
• Coordinates: 367251..367538 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CCS77_RS01840
• Protein ID: WP_084042015.1
• Coordinates: 367010..367261 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS77_RS01825	363120..364144	+	1025	Protein_347	ABC transporter substrate-binding protein	-
CCS77_RS01830	364236..364487	+	252	WP_107916391.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CCS77_RS01835	365147..366928	+	1782	WP_107916392.1	site-specific integrase	-
CCS77_RS01840	367010..367261	+	252	WP_084042015.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CCS77_RS01845	367251..367538	+	288	WP_021084979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCS77_RS01850	367905..368234	+	330	WP_107916393.1	plasmid mobilization relaxosome protein MobC	-
CCS77_RS01855	368282..369874	+	1593	WP_107916394.1	relaxase/mobilization nuclease domain-containing protein	-
CCS77_RS01860	370551..370724	-	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CCS77_RS10420	370786..371623	-	838	Protein_355	ATP-binding protein	-
CCS77_RS10455	371822..372166	-	345	WP_009295465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11387.25 Da
• Isoelectric Point: 9.5216

>T76871 WP_021084979.1 NZ_CP021642:367251-367538 [Campylobacter concisus]
MSYELEFLPSALKEWQKLDNSIKVQFKKKLSERLENPKVTKDKLRGYEDVYKIKLRDVGYRLAYQVKDDEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T76871 NZ_CP021642:367251-367538 [Campylobacter concisus]
ATGAGTTATGAGTTAGAGTTCTTGCCAAGTGCTTTAAAAGAGTGGCAAAAGCTTGACAATAGCATAAAAGTGCAGTTTAA
AAAGAAGCTAAGTGAGCGTCTAGAAAACCCAAAGGTTACCAAAGACAAGCTACGAGGCTATGAAGATGTCTACAAGATCA
AGCTAAGAGATGTCGGCTACCGCTTGGCATATCAAGTAAAAGATGACGAGATCGTAGTATTGGTGCTAGTTGTCGGCAAA
AGAGAGAATAACGAAGTGTATGAGATGCTAAAGGATAAATTTAACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8954.26 Da
• Isoelectric Point: 4.9901

>AT76871 WP_084042015.1 NZ_CP021642:367010-367261 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSSVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT76871 NZ_CP021642:367010-367261 [Campylobacter concisus]
ATGCAAACCATACAAGCAAATTTCACAGCTAGCATAAGCGAGCTAAAAAAGTCTCCAGCTCAAATTTTAAAACAAGCTGG
AGATAATGTTGTAGCTATACTAAACCACAATGTCCCTAGCGCCTATCTAGTACCCAGCTCTGTCTATGAAAAAATGGCAG
AGATAATAGAAGAGTATCATCTAAGTAAAGCAGTAGACGCTGCTCTAGCAAGTGGTGAAAAACCAGTAAAAGTAAGTCTA
GATGAGTTATGA

Structures

Toxin

• AlphaFold DB: U2FZT6