Detailed information of TA system TA076868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1581064..1581676
• Replicon: chromosome
• Accession: NZ_CP021640
• Organism: Streptococcus pyogenes strain JS12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CCX85_RS07970
• Protein ID: WP_038432559.1
• Coordinates: 1581341..1581676 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CCX85_RS07965
• Protein ID: WP_101248450.1
• Coordinates: 1581064..1581351 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX85_RS07935	1576244..1577227	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
CCX85_RS07940	1577231..1578160	-	930	WP_020837785.1	tagatose-6-phosphate kinase	-
CCX85_RS07945	1578206..1578721	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
CCX85_RS07950	1578756..1579184	-	429	WP_101248449.1	galactose-6-phosphate isomerase subunit LacA	-
CCX85_RS07955	1579630..1580403	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
CCX85_RS07965	1581064..1581351	+	288	WP_101248450.1	hypothetical protein	Antitoxin
CCX85_RS07970	1581341..1581676	+	336	WP_038432559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCX85_RS09240	1581828..1582298	+	471	Protein_1473	tyrosine-type recombinase/integrase family protein	-
CCX85_RS09245	1582659..1582808	+	150	WP_011285175.1	integrase	-
CCX85_RS07990	1582940..1583332	-	393	WP_002982716.1	30S ribosomal protein S9	-
CCX85_RS07995	1583353..1583799	-	447	WP_002982710.1	50S ribosomal protein L13	-
CCX85_RS08000	1584017..1584223	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
CCX85_RS08005	1584220..1584726	-	507	WP_002988070.1	hypothetical protein	-
CCX85_RS08010	1584862..1585722	-	861	WP_002982687.1	DegV family protein	-
CCX85_RS08015	1585819..1586337	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13159.91 Da
• Isoelectric Point: 5.2144

>T76868 WP_038432559.1 NZ_CP021640:1581341-1581676 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIILYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T76868 NZ_CP021640:1581341-1581676 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTATCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10933.62 Da
• Isoelectric Point: 8.5312

>AT76868 WP_101248450.1 NZ_CP021640:1581064-1581351 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIKDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT76868 NZ_CP021640:1581064-1581351 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTAAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA