Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1399298..1399864 Replicon chromosome
Accession NZ_CP021556
Organism Bifidobacterium breve strain 139W423

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag BB139W423_RS06375 Protein ID WP_014483710.1
Coordinates 1399571..1399864 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag BB139W423_RS06370 Protein ID WP_014483711.1
Coordinates 1399298..1399567 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB139W423_RS06345 1395039..1395734 - 696 WP_003829410.1 response regulator transcription factor -
BB139W423_RS06350 1395860..1396375 + 516 WP_013140733.1 hypothetical protein -
BB139W423_RS06355 1396372..1397262 + 891 WP_003831809.1 hypothetical protein -
BB139W423_RS06360 1397259..1397947 + 689 Protein_1195 ABC transporter ATP-binding protein -
BB139W423_RS06365 1397944..1399113 + 1170 WP_051317546.1 ABC transporter permease -
BB139W423_RS06370 1399298..1399567 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB139W423_RS06375 1399571..1399864 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
BB139W423_RS06385 1400533..1401084 + 552 WP_015438834.1 RNA polymerase sigma factor -
BB139W423_RS06390 1401118..1401945 + 828 WP_015438835.1 hypothetical protein -
BB139W423_RS06395 1402077..1402703 + 627 WP_015438836.1 hypothetical protein -
BB139W423_RS06400 1402700..1403482 + 783 WP_021649673.1 hypothetical protein -
BB139W423_RS06405 1403535..1404410 + 876 WP_021649674.1 ABC transporter ATP-binding protein -
BB139W423_RS06410 1404464..1404862 + 399 WP_016462921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1393198..1411585 18387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T76860 WP_014483710.1 NZ_CP021556:1399571-1399864 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T76860 NZ_CP021556:1399571-1399864 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76860 WP_014483711.1 NZ_CP021556:1399298-1399567 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76860 NZ_CP021556:1399298-1399567 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References