Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1289381..1289947 Replicon chromosome
Accession NZ_CP021555
Organism Bifidobacterium breve strain 082W48

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BB082W48_RS05780 Protein ID WP_106622321.1
Coordinates 1289654..1289947 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BB082W48_RS05775 Protein ID WP_025221722.1
Coordinates 1289381..1289650 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB082W48_RS05750 1285131..1285826 - 696 WP_106622320.1 response regulator transcription factor -
BB082W48_RS05755 1285952..1286467 + 516 WP_013140733.1 hypothetical protein -
BB082W48_RS05760 1286464..1287354 + 891 WP_007056280.1 hypothetical protein -
BB082W48_RS05765 1287351..1288031 + 681 WP_052787988.1 ABC transporter ATP-binding protein -
BB082W48_RS05770 1288028..1289173 + 1146 Protein_1076 ABC transporter permease -
BB082W48_RS05775 1289381..1289650 + 270 WP_025221722.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB082W48_RS05780 1289654..1289947 + 294 WP_106622321.1 type II toxin-antitoxin system YafQ family toxin Toxin
BB082W48_RS05790 1290604..1291155 + 552 WP_052789591.1 RNA polymerase sigma factor -
BB082W48_RS05795 1291189..1292016 + 828 WP_106622323.1 hypothetical protein -
BB082W48_RS05800 1292149..1292775 + 627 WP_003829423.1 hypothetical protein -
BB082W48_RS05805 1292772..1293554 + 783 WP_106622324.1 murein hydrolase transporter LrgB -
BB082W48_RS05810 1293606..1294481 + 876 WP_106622325.1 ABC transporter ATP-binding protein -
BB082W48_RS05815 1294536..1294934 + 399 WP_015438839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-88)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.06 Da        Isoelectric Point: 9.7881

>T76858 WP_106622321.1 NZ_CP021555:1289654-1289947 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLVK

Download         Length: 294 bp

>T76858 NZ_CP021555:1289654-1289947 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGTCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.22 Da        Isoelectric Point: 6.3186

>AT76858 WP_025221722.1 NZ_CP021555:1289381-1289650 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMKALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76858 NZ_CP021555:1289381-1289650 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGAAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References