Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1291551..1292117 Replicon chromosome
Accession NZ_CP021554
Organism Bifidobacterium breve strain 017W439

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag BB017W439_RS05875 Protein ID WP_014483710.1
Coordinates 1291824..1292117 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag BB017W439_RS05870 Protein ID WP_014483711.1
Coordinates 1291551..1291820 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB017W439_RS05845 1287300..1287995 - 696 WP_003829410.1 response regulator transcription factor -
BB017W439_RS05850 1288121..1288636 + 516 WP_013140733.1 hypothetical protein -
BB017W439_RS05855 1288633..1289523 + 891 WP_106648787.1 hypothetical protein -
BB017W439_RS05860 1289520..1290200 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
BB017W439_RS05865 1290197..1291366 + 1170 WP_106641557.1 ABC transporter permease -
BB017W439_RS05870 1291551..1291820 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB017W439_RS05875 1291824..1292117 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
BB017W439_RS10540 1292748..1293041 + 294 WP_012471870.1 hypothetical protein -
BB017W439_RS05890 1293689..1293801 + 113 Protein_1093 permease -
BB017W439_RS10545 1294273..1294469 + 197 Protein_1094 permease -
BB017W439_RS05900 1294793..1296373 + 1581 WP_025262999.1 amino acid permease -
BB017W439_RS05905 1296615..1296854 - 240 WP_014483708.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1285459..1294464 9005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T76856 WP_014483710.1 NZ_CP021554:1291824-1292117 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T76856 NZ_CP021554:1291824-1292117 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76856 WP_014483711.1 NZ_CP021554:1291551-1291820 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76856 NZ_CP021554:1291551-1291820 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References