Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1389334..1389900 Replicon chromosome
Accession NZ_CP021553
Organism Bifidobacterium breve strain DRBB28

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7CVW6
Locus tag DRBB28_RS06490 Protein ID WP_052790763.1
Coordinates 1389607..1389900 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7CVI8
Locus tag DRBB28_RS06485 Protein ID WP_052790764.1
Coordinates 1389334..1389603 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRBB28_RS06460 1385083..1385778 - 696 WP_003829410.1 response regulator transcription factor -
DRBB28_RS06465 1385904..1386419 + 516 WP_013140733.1 hypothetical protein -
DRBB28_RS06470 1386416..1387306 + 891 WP_003831809.1 hypothetical protein -
DRBB28_RS06475 1387303..1387983 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
DRBB28_RS06480 1387980..1389149 + 1170 WP_106642017.1 ABC transporter permease -
DRBB28_RS06485 1389334..1389603 + 270 WP_052790764.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DRBB28_RS06490 1389607..1389900 + 294 WP_052790763.1 type II toxin-antitoxin system YafQ family toxin Toxin
DRBB28_RS06495 1390008..1390304 + 297 WP_041473342.1 transporter -
DRBB28_RS06500 1390591..1392168 + 1578 WP_014483709.1 amino acid permease -
DRBB28_RS06505 1392410..1392649 - 240 WP_014483708.1 hypothetical protein -
DRBB28_RS06510 1392946..1393299 + 354 WP_014483707.1 DUF488 domain-containing protein -
DRBB28_RS11465 1393365..1393793 - 429 WP_003831803.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11218.94 Da        Isoelectric Point: 9.8306

>T76854 WP_052790763.1 NZ_CP021553:1389607-1389900 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRTHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

>T76854 NZ_CP021553:1389607-1389900 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCACCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9832.11 Da        Isoelectric Point: 4.5742

>AT76854 WP_052790764.1 NZ_CP021553:1389334-1389603 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTTVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76854 NZ_CP021553:1389334-1389603 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7CVW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7CVI8

References