Detailed information of TA system TA076846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 2720768..2721467
• Replicon: chromosome
• Accession: NZ_CP021550
• Organism: Proteus mirabilis strain AR_0159

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: AM405_RS12720
• Protein ID: WP_004249093.1
• Coordinates: 2721081..2721467 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AM405_RS12715
• Protein ID: WP_004246828.1
• Coordinates: 2720768..2721088 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM405_RS12685	2715899..2716174	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
AM405_RS12690	2716229..2716852	-	624	WP_004246821.1	guanylate kinase	-
AM405_RS12695	2717153..2717770	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AM405_RS12700	2717907..2719193	+	1287	WP_087741020.1	DUF3748 domain-containing protein	-
AM405_RS12705	2719408..2720292	+	885	WP_004249091.1	endonuclease/exonuclease/phosphatase family protein	-
AM405_RS12710	2720285..2720719	+	435	WP_004246827.1	hypothetical protein	-
AM405_RS12715	2720768..2721088	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AM405_RS12720	2721081..2721467	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM405_RS12725	2721629..2723701	-	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
AM405_RS12730	2723711..2724616	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AM405_RS12735	2724867..2725448	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T76846 WP_004249093.1 NZ_CP021550:c2721467-2721081 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T76846 NZ_CP021550:c2721467-2721081 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT76846 WP_004246828.1 NZ_CP021550:c2721088-2720768 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT76846 NZ_CP021550:c2721088-2720768 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97