76819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4941299..4941956 Replicon chromosome
Accession NZ_CP021539
Organism Klebsiella pneumoniae strain AR_0047

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM426_RS24805 Protein ID WP_002916310.1
Coordinates 4941299..4941709 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM426_RS24810 Protein ID WP_002916312.1
Coordinates 4941690..4941956 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM426_RS24785 4937299..4939032 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
AM426_RS24790 4939038..4939751 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM426_RS24795 4939774..4940670 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM426_RS24800 4940771..4941292 + 522 WP_002916308.1 flavodoxin FldB -
AM426_RS24805 4941299..4941709 - 411 WP_002916310.1 protein YgfX Toxin
AM426_RS24810 4941690..4941956 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM426_RS24815 4942202..4943185 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AM426_RS24820 4943336..4943995 - 660 WP_002916317.1 hemolysin III family protein -
AM426_RS24825 4944159..4944470 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
AM426_RS24830 4944520..4945248 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM426_RS24835 4945367..4946800 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T76819 WP_002916310.1 NZ_CP021539:c4941709-4941299 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T76819 NZ_CP021539:c4941709-4941299 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT76819 WP_002916312.1 NZ_CP021539:c4941956-4941690 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT76819 NZ_CP021539:c4941956-4941690 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References