Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 244135..244685 Replicon plasmid pAP1447-1
Accession NZ_CP021525
Organism Acetobacter ascendens strain SRCM101447

Toxin (Protein)


Gene name relE Uniprot ID C7JII7
Locus tag S101447_RS14810 Protein ID WP_003618711.1
Coordinates 244135..244428 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5QDQ9
Locus tag S101447_RS14815 Protein ID WP_003618686.1
Coordinates 244425..244685 (-) Length 87 a.a.

Genomic Context

S101447_RS14785S101447_RS14795S101447_RS14840S101447_RS14800S101447_RS14805S101447_RS14810S101447_RS14815S101447_RS14820S101447_RS14825S101447_RS14830S101447_RS14835
Location: 239937..240590 (654 bp)
Type: Others
Protein ID: WP_087636619.1
Location: 240642..241852 (1211 bp)
Type: Others
Protein ID: WP_087636566.1
Location: 248011..248901 (891 bp)
Type: Others
Protein ID: WP_019092362.1
Location: 242058..242741 (684 bp)
Type: Others
Protein ID: WP_019092458.1
Location: 242741..244003 (1263 bp)
Type: Others
Protein ID: WP_019092457.1
Location: 244135..244428 (294 bp)
Type: Toxin
Protein ID: WP_003618711.1
Location: 244425..244685 (261 bp)
Type: Antitoxin
Protein ID: WP_003618686.1
Location: 244919..245695 (777 bp)
Type: Others
Protein ID: WP_019092456.1
Location: 245768..246355 (588 bp)
Type: Others
Protein ID: WP_087636567.1
Location: 246376..247401 (1026 bp)
Type: Others
Protein ID: WP_087636568.1
Location: 247391..247792 (402 bp)
Type: Others
Protein ID: WP_019092361.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
S101447_RS14785239937..240590+654WP_087636619.1arsenical resistance protein ArsH-
S101447_RS14795240642..241852+1211WP_087636566.1IS3 family transposase-
S101447_RS14800242058..242741-684WP_019092458.1DUF1275 domain-containing protein-
S101447_RS14805242741..244003-1263WP_019092457.1sodium:proton antiporter-
S101447_RS14810244135..244428-294WP_003618711.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
S101447_RS14815244425..244685-261WP_003618686.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
S101447_RS14820244919..245695-777WP_019092456.1SDR family oxidoreductase-
S101447_RS14825245768..246355-588WP_087636567.1DNA-3-methyladenine glycosylase I-
S101447_RS14830246376..247401-1026WP_087636568.1saccharopine dehydrogenase NADP-binding domain-containing protein-
S101447_RS14835247391..247792-402WP_019092361.1VOC family protein-
S101447_RS14840248011..248901+891WP_019092362.1AraC family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..336151336151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11605.35 Da        Isoelectric Point: 7.9998

>T76731 WP_003618711.1 NZ_CP021525:c244428-244135 [Acetobacter ascendens]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Download         Length: 294 bp

>T76731 NZ_CP021525:c244428-244135 [Acetobacter ascendens]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCACTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9762.23 Da        Isoelectric Point: 10.4645

>AT76731 WP_003618686.1 NZ_CP021525:c244685-244425 [Acetobacter ascendens]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Download         Length: 261 bp

>AT76731 NZ_CP021525:c244685-244425 [Acetobacter ascendens]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6N3T9M6

References