Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 144735..145312 Replicon plasmid pAP1447-1
Accession NZ_CP021525
Organism Acetobacter ascendens strain SRCM101447

Toxin (Protein)


Gene name vapC Uniprot ID A0A401XH43
Locus tag S101447_RS14270 Protein ID WP_019089356.1
Coordinates 144735..145043 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A401XH51
Locus tag S101447_RS14275 Protein ID WP_019089357.1
Coordinates 145040..145312 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S101447_RS14225 139806..140627 + 822 WP_087636536.1 hypothetical protein -
S101447_RS14230 140743..141591 + 849 WP_087636537.1 hypothetical protein -
S101447_RS14235 141594..142058 + 465 WP_019089349.1 hypothetical protein -
S101447_RS14240 142155..142970 + 816 WP_019089350.1 hypothetical protein -
S101447_RS14245 142983..143387 + 405 WP_019089351.1 hypothetical protein -
S101447_RS14250 143444..143764 - 321 WP_026019385.1 hypothetical protein -
S101447_RS14255 143794..143994 - 201 WP_019089353.1 hypothetical protein -
S101447_RS14260 144051..144380 - 330 WP_019089354.1 endoribonuclease MazF -
S101447_RS14265 144382..144636 - 255 WP_019089355.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
S101447_RS14270 144735..145043 - 309 WP_019089356.1 PIN domain-containing protein Toxin
S101447_RS14275 145040..145312 - 273 WP_019089357.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
S101447_RS14280 145385..145801 - 417 WP_087636538.1 hypothetical protein -
S101447_RS14285 145798..146232 - 435 WP_087636539.1 plasmid protein -
S101447_RS14290 146296..146793 - 498 WP_087636540.1 single-stranded DNA-binding protein -
S101447_RS15770 147554..147700 - 147 WP_157894002.1 hypothetical protein -
S101447_RS15775 147699..147866 + 168 WP_157893992.1 hypothetical protein -
S101447_RS14300 148050..148730 - 681 WP_019089472.1 hypothetical protein -
S101447_RS15780 148729..149001 + 273 WP_150178215.1 hypothetical protein -
S101447_RS14305 149282..149635 + 354 WP_150178214.1 hypothetical protein -
S101447_RS14310 149631..150015 - 385 Protein_157 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..336151 336151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-76)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11094.83 Da        Isoelectric Point: 4.3321

>T76730 WP_019089356.1 NZ_CP021525:c145043-144735 [Acetobacter ascendens]
VSIYLLDTNISSDFVRNPSGSCAQRIELIDPDDLCTSIIVAAELRYGCAKKGSEKLLNRVESVLAFIPVLILDIPADCEY
GGIRAELEAAGRTIGMLEKFFA

Download         Length: 309 bp

>T76730 NZ_CP021525:c145043-144735 [Acetobacter ascendens]
GTGAGCATCTACCTTCTTGATACAAACATCAGCAGCGATTTCGTGCGCAACCCTTCCGGCTCCTGTGCACAACGCATTGA
GCTTATTGACCCAGATGATCTTTGCACCAGCATCATCGTGGCCGCAGAATTACGCTATGGATGCGCCAAAAAAGGCTCCG
AAAAGCTCTTGAACCGGGTCGAAAGCGTGTTGGCGTTTATCCCTGTGCTGATACTCGATATTCCTGCCGACTGTGAATAC
GGTGGCATCCGCGCCGAACTCGAAGCAGCAGGGCGGACAATCGGCATGCTGGAGAAGTTTTTTGCGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10390.00 Da        Isoelectric Point: 4.7064

>AT76730 WP_019089357.1 NZ_CP021525:c145312-145040 [Acetobacter ascendens]
MPVPEVTPRSREVKLFRNNRSQAVRIPVEFEMPGDRVMIRRDGDKLVLEPVKTPSTLKELLMAWREEPQLPPEDDFPDIQ
DVAARPEGIL

Download         Length: 273 bp

>AT76730 NZ_CP021525:c145312-145040 [Acetobacter ascendens]
ATGCCAGTTCCTGAAGTGACCCCCAGATCGCGCGAAGTAAAACTCTTTCGGAATAATCGCAGTCAGGCCGTGCGGATTCC
GGTCGAATTTGAAATGCCGGGAGATCGTGTAATGATCCGCCGTGACGGTGACAAACTCGTTCTGGAGCCTGTGAAGACGC
CTTCCACGCTGAAGGAGCTTCTCATGGCATGGCGTGAAGAGCCGCAGCTGCCTCCCGAAGACGATTTTCCCGATATTCAG
GATGTTGCCGCCAGACCAGAAGGTATCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401XH43

Antitoxin

Source ID Structure
AlphaFold DB A0A401XH51

References