Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2870666..2871240 Replicon chromosome
Accession NZ_CP021524
Organism Acetobacter ascendens strain SRCM101447

Toxin (Protein)


Gene name hicA Uniprot ID A0A2G4RF69
Locus tag S101447_RS13360 Protein ID WP_035365565.1
Coordinates 2871052..2871240 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag S101447_RS13355 Protein ID WP_087636328.1
Coordinates 2870666..2871055 (-) Length 130 a.a.

Genomic Context

S101447_RS15885S101447_RS13325S101447_RS13335S101447_RS13340S101447_RS13345S101447_RS13350S101447_RS13365S101447_RS13370S101447_RS13375S101447_RS13380S101447_RS13330S101447_RS13355S101447_RS13360
Location: 2866517..2866786 (270 bp)
Type: Others
Protein ID: WP_087636448.1
Location: 2866735..2867226 (492 bp)
Type: Others
Protein ID: WP_087636324.1
Location: 2868337..2868747 (411 bp)
Type: Others
Protein ID: WP_087636326.1
Location: 2868897..2869656 (760 bp)
Type: Others
Protein ID: Protein_2573
Location: 2869694..2870326 (633 bp)
Type: Others
Protein ID: WP_003628645.1
Location: 2870323..2870652 (330 bp)
Type: Others
Protein ID: WP_087636327.1
Location: 2871458..2872060 (603 bp)
Type: Others
Protein ID: WP_087636329.1
Location: 2872044..2873735 (1692 bp)
Type: Others
Protein ID: WP_087636330.1
Location: 2873723..2875033 (1311 bp)
Type: Others
Protein ID: WP_087636331.1
Location: 2875040..2875783 (744 bp)
Type: Others
Protein ID: WP_087636332.1
Location: 2867219..2868205 (987 bp)
Type: Others
Protein ID: WP_087636325.1
Location: 2870666..2871055 (390 bp)
Type: Antitoxin
Protein ID: WP_087636328.1
Location: 2871052..2871240 (189 bp)
Type: Toxin
Protein ID: WP_035365565.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
S101447_RS158852866517..2866786+270WP_087636448.1hypothetical protein-
S101447_RS133252866735..2867226+492WP_087636324.1hypothetical protein-
S101447_RS133302867219..2868205-987WP_087636325.1FRG domain-containing protein-
S101447_RS133352868337..2868747+411WP_087636326.1hypothetical protein-
S101447_RS133402868897..2869656+760Protein_2573tyrosine-type recombinase/integrase-
S101447_RS133452869694..2870326+633WP_003628645.1DUF3164 family protein-
S101447_RS133502870323..2870652+330WP_087636327.1HNH endonuclease-
S101447_RS133552870666..2871055-390WP_087636328.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
S101447_RS133602871052..2871240-189WP_035365565.1type II toxin-antitoxin system HicA family toxinToxin
S101447_RS133652871458..2872060+603WP_087636329.1terminase-
S101447_RS133702872044..2873735+1692WP_087636330.1terminase large subunit-
S101447_RS133752873723..2875033+1311WP_087636331.1phage portal protein-
S101447_RS133802875040..2875783+744WP_087636332.1Clp protease ClpP-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2858373..288649828125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-119)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7018.25 Da        Isoelectric Point: 11.1497

>T76726 WP_035365565.1 NZ_CP021524:c2871240-2871052 [Acetobacter ascendens]
MDSREIIKKIKADGWYLVATKGSHQQFKHPTKPGRVTVPHPKRDLPLGTLRSVEKQSGVKLK

Download         Length: 189 bp

>T76726 NZ_CP021524:c2871240-2871052 [Acetobacter ascendens]
ATGGACAGCAGAGAGATCATCAAGAAGATCAAGGCAGACGGCTGGTATCTTGTCGCCACGAAAGGCAGTCATCAGCAGTT
CAAGCACCCGACAAAACCCGGCCGGGTGACGGTGCCTCACCCTAAGCGGGATCTTCCACTCGGCACTCTGCGGAGCGTAG
AGAAACAATCAGGGGTCAAACTGAAATGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14050.94 Da        Isoelectric Point: 4.7313

>AT76726 WP_087636328.1 NZ_CP021524:c2871055-2870666 [Acetobacter ascendens]
MSDYIAIIHKEPESDFGVSFPDFPGCITAGSSLEEARKMAQEALEFHISGMTEDGESIPAPSPLDKVMQDPNFAQGVAFM
VHVRLPSKAVRVNVTLDESLVSAIAAVSKNRSKFLAEAAWEKLNRNQSV

Download         Length: 390 bp

>AT76726 NZ_CP021524:c2871055-2870666 [Acetobacter ascendens]
ATGAGCGACTATATCGCCATCATCCACAAAGAGCCCGAAAGTGATTTCGGGGTCAGCTTTCCAGATTTTCCCGGCTGCAT
CACAGCAGGCTCTTCATTGGAAGAAGCCCGGAAAATGGCCCAGGAAGCCTTGGAATTCCATATCTCTGGCATGACAGAAG
ATGGTGAGTCCATCCCTGCGCCATCGCCTTTGGATAAGGTCATGCAGGATCCGAACTTTGCTCAAGGTGTTGCCTTCATG
GTTCATGTTCGGCTGCCTTCCAAAGCCGTGCGTGTGAACGTCACGTTGGACGAAAGCCTTGTGTCCGCCATTGCAGCTGT
CAGCAAAAACCGCTCCAAATTTCTGGCTGAAGCCGCATGGGAAAAACTGAACCGTAATCAGTCTGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2G4RF69

Antitoxin

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Source
ID
Structure
No matching records found

References