Detailed information of TA system TA076719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 106228..106856
• Replicon: plasmid pAP1342-3
• Accession: NZ_CP021512
• Organism: Acetobacter pasteurianus subsp. Pasteurianus strain SRCM101342

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: S1001342_RS14835
• Protein ID: WP_003630720.1
• Coordinates: 106452..106856 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C7JJ36
• Locus tag: S1001342_RS14830
• Protein ID: WP_012813340.1
• Coordinates: 106228..106452 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S1001342_RS14815	102535..103557	+	1023	WP_087652277.1	IS110 family transposase	-
S1001342_RS14820	103834..104427	-	594	Protein_95	IS110 family transposase	-
S1001342_RS14825	104689..106122	+	1434	WP_087652209.1	hypothetical protein	-
S1001342_RS14830	106228..106452	+	225	WP_012813340.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
S1001342_RS14835	106452..106856	+	405	WP_003630720.1	tRNA(fMet)-specific endonuclease VapC	Toxin
S1001342_RS14840	107064..107264	+	201	WP_012813343.1	type II toxin-antitoxin system CcdA family antitoxin	-
S1001342_RS14845	107265..107570	+	306	WP_042788970.1	CcdB family protein	-
S1001342_RS14855	107657..108619	+	963	Protein_101	tyrosine-type recombinase/integrase	-
S1001342_RS14860	109027..109950	+	924	WP_012813117.1	plasmid replication initiator RepA	-
S1001342_RS14865	110160..111215	+	1056	WP_012813118.1	DUF1870 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..256755	256755

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 17321.52 Da
• Isoelectric Point: 12.9270

>T76719 WP_003630720.1 NZ_CP021512:106452-106856 [Acetobacter pasteurianus subsp. Pasteurianus]
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KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 405 bp

>T76719 NZ_CP021512:106452-106856 [Acetobacter pasteurianus subsp. Pasteurianus]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 9631.07 Da
• Isoelectric Point: 12.6692

>AT76719 WP_012813340.1 NZ_CP021512:106228-106452 [Acetobacter pasteurianus subsp. Pasteurianus]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 225 bp

>AT76719 NZ_CP021512:106228-106452 [Acetobacter pasteurianus subsp. Pasteurianus]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A511FS67