Detailed information of TA system TA076717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-mazE/VapC-MazE
• Location: 111927..112630
• Replicon: plasmid pAP1342-2
• Accession: NZ_CP021511
• Organism: Acetobacter pasteurianus subsp. Pasteurianus strain SRCM101342

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: S1001342_RS14000
• Protein ID: WP_087652235.1
• Coordinates: 112280..112630 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: C7JIL0
• Locus tag: S1001342_RS13995
• Protein ID: WP_006115554.1
• Coordinates: 111927..112181 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S1001342_RS13955	107382..108170	+	789	WP_087652215.1	hypothetical protein	-
S1001342_RS13960	108287..109135	+	849	WP_039891563.1	hypothetical protein	-
S1001342_RS13965	109138..109602	+	465	WP_039891560.1	hypothetical protein	-
S1001342_RS13970	109699..110515	+	817	Protein_116	hypothetical protein	-
S1001342_RS13975	110528..110932	+	405	Protein_117	hypothetical protein	-
S1001342_RS13980	110989..111309	-	321	WP_012813211.1	hypothetical protein	-
S1001342_RS13985	111339..111539	-	201	WP_012813212.1	hypothetical protein	-
S1001342_RS13990	111596..111925	-	330	WP_012813213.1	endoribonuclease MazF	-
S1001342_RS13995	111927..112181	-	255	WP_006115554.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
S1001342_RS14000	112280..112630	-	351	WP_087652235.1	PIN domain-containing protein	Toxin
S1001342_RS14005	112668..113708	+	1041	WP_012813095.1	IS110 family transposase	-
S1001342_RS14010	114252..115274	-	1023	WP_087652186.1	IS110 family transposase	-
S1001342_RS14015	115536..116921	-	1386	WP_087652198.1	IS1380-like element IS1380A family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..190983	190983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-93)

Antitoxin

• Post-segregation antitoxin CcdA (8-77)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T76717 WP_087652235.1 NZ_CP021511:c112630-112280 [Acetobacter pasteurianus subsp. Pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T76717 NZ_CP021511:c112630-112280 [Acetobacter pasteurianus subsp. Pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 12528.03 Da
• Isoelectric Point: 5.5500

>AT76717 WP_006115554.1 NZ_CP021511:c112181-111927 [Acetobacter pasteurianus subsp. Pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFF

Nucleotide

• Length: 255 bp

>AT76717 NZ_CP021511:c112181-111927 [Acetobacter pasteurianus subsp. Pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A6P1QDC4