Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1373112..1374028 | Replicon | chromosome |
| Accession | NZ_CP021500 | ||
| Organism | Bacillus atrophaeus strain SRCM101359 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A7U5BWH7 |
| Locus tag | S101359_RS06840 | Protein ID | WP_003327423.1 |
| Coordinates | 1373282..1374028 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | - |
| Locus tag | S101359_RS06835 | Protein ID | WP_061670599.1 |
| Coordinates | 1373112..1373282 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| S101359_RS06805 | 1369868..1370197 | + | 330 | WP_088116995.1 | XkdW family protein | - |
| S101359_RS06810 | 1370194..1370358 | + | 165 | WP_003327430.1 | XkdX family protein | - |
| S101359_RS06815 | 1370434..1371282 | + | 849 | WP_088116996.1 | phage portal protein | - |
| S101359_RS06820 | 1371356..1371634 | + | 279 | WP_003327427.1 | hemolysin XhlA family protein | - |
| S101359_RS06825 | 1371647..1371910 | + | 264 | WP_003327426.1 | phage holin | - |
| S101359_RS06830 | 1371923..1372816 | + | 894 | WP_088116997.1 | N-acetylmuramoyl-L-alanine amidase | - |
| S101359_RS20930 | 1372892..1373014 | - | 123 | WP_010788356.1 | hypothetical protein | - |
| S101359_RS06835 | 1373112..1373282 | - | 171 | WP_061670599.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| S101359_RS06840 | 1373282..1374028 | - | 747 | WP_003327423.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| S101359_RS06845 | 1374137..1375135 | - | 999 | WP_088116998.1 | inorganic phosphate transporter | - |
| S101359_RS06850 | 1375148..1375765 | - | 618 | WP_003327421.1 | DUF47 domain-containing protein | - |
| S101359_RS06855 | 1376053..1377369 | - | 1317 | WP_003327418.1 | amino acid permease | - |
| S101359_RS06860 | 1377789..1378739 | + | 951 | WP_088116999.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1340793..1394824 | 54031 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29110.66 Da Isoelectric Point: 4.5650
>T76711 WP_003327423.1 NZ_CP021500:c1374028-1373282 [Bacillus atrophaeus]
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALIDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG
Download Length: 747 bp
>T76711 NZ_CP021500:c1374028-1373282 [Bacillus atrophaeus]
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTGGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTGATCGGCGCCATGGTATACTGGA
CGTATGACCCCTCTTCTCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGATTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCCGAGGGCATCGATAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCGCTG
TGTGAATATTCGACACAGCTAGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTATGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACATCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA
ATGCTTTTATTCTTTCAGATTATGGTTTGGTGCATAATGGCCGCATTGGGCCTATACGTATATGCGGTGTGGCGGTTTGA
AGCAAAGGTGAAAGAAAAAATGTTTGCGATCCGGAAAACGTGGTATTTGATCTTTGTGATCGGCGCCATGGTATACTGGA
CGTATGACCCCTCTTCTCTTTTCAGGGAATGGACGAATTATTTGATTGTCGCTGTCAGCTTTGCTTTGATTGACGCCTTT
ATCTTTTTGAGCGCTTACGTAAAGAAACTTGCCGGCAATGAATTAGAAACCGACACACGGGAAATCCTTGAAGAAAACAA
TGAAATGCTCCACGTTTATCTTGATAAATTAAAAACGTACCAATACCTATTGAAAAATGAACCGATCCATGTTTATTATG
GAAGTATAGAAGCATACGCCGAGGGCATCGATAAGCTGCTCAAAACCTATGCCGACAAAATGAACTTAACGGCTTCGCTG
TGTGAATATTCGACACAGCTAGAAAAAGACCGCTTAACCGAGCATATGGATGATGCATTTGAGGTGCAGAGCCGGCTGGA
TCGAAAAGATGTATACTATGATCAGCACGGGAAGCTGGCACTCATCCCTTTTACAGTCCAGACACGCAGCTATGTCATCA
AGCTGGCGTCAGACAGCATTGTAACAGAATTTGATTATTTGCTTTTCACATCATTAACTAGCATTTACGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGACGGATAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6609.58 Da Isoelectric Point: 11.0258
>AT76711 WP_061670599.1 NZ_CP021500:c1373282-1373112 [Bacillus atrophaeus]
MERAFQNDHSTRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNDHSTRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT76711 NZ_CP021500:c1373282-1373112 [Bacillus atrophaeus]
ATGGAACGTGCTTTTCAAAACGATCATTCGACCCGCGCGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAACCACCAG
CGTCGCAAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA
ATGGAACGTGCTTTTCAAAACGATCATTCGACCCGCGCGGCTAAACCGTTTAAGATATTAAAAAAGAGATCAACCACCAG
CGTCGCAAGCTATCAGGTCAGCCCCCACACGGCAAGAATTTTCAAAGAAAATGAGCGGCTGATTGACGAGTATAAAAGAA
AAAAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|