Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 529847..530483 | Replicon | chromosome |
Accession | NZ_CP021500 | ||
Organism | Bacillus atrophaeus strain SRCM101359 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | S101359_RS02625 | Protein ID | WP_003156187.1 |
Coordinates | 530133..530483 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A837XXL9 |
Locus tag | S101359_RS02620 | Protein ID | WP_003328141.1 |
Coordinates | 529847..530128 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
S101359_RS02600 | 526145..526744 | - | 600 | WP_088116551.1 | rhomboid family intramembrane serine protease | - |
S101359_RS02605 | 526843..527208 | + | 366 | WP_088116552.1 | holo-ACP synthase | - |
S101359_RS02610 | 527376..528392 | + | 1017 | WP_088116553.1 | outer membrane lipoprotein carrier protein LolA | - |
S101359_RS02615 | 528559..529728 | + | 1170 | WP_088116554.1 | alanine racemase | - |
S101359_RS02620 | 529847..530128 | + | 282 | WP_003328141.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
S101359_RS02625 | 530133..530483 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
S101359_RS02630 | 530599..531417 | + | 819 | WP_003328142.1 | STAS domain-containing protein | - |
S101359_RS02635 | 531422..531787 | + | 366 | WP_010789626.1 | RsbT antagonist protein RsbS | - |
S101359_RS02640 | 531790..532191 | + | 402 | WP_003328144.1 | serine/threonine-protein kinase RsbT | - |
S101359_RS02645 | 532203..533210 | + | 1008 | WP_088116555.1 | PP2C family protein-serine/threonine phosphatase | - |
S101359_RS02650 | 533270..533599 | + | 330 | WP_010789624.1 | anti-sigma factor antagonist RsbV | - |
S101359_RS02655 | 533596..534078 | + | 483 | WP_003328147.1 | anti-sigma B factor RsbW | - |
S101359_RS02660 | 534044..534832 | + | 789 | WP_003328149.1 | RNA polymerase sigma factor SigB | - |
S101359_RS02665 | 534832..535431 | + | 600 | WP_003328150.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T76710 WP_003156187.1 NZ_CP021500:530133-530483 [Bacillus atrophaeus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T76710 NZ_CP021500:530133-530483 [Bacillus atrophaeus]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10451.83 Da Isoelectric Point: 5.1903
>AT76710 WP_003328141.1 NZ_CP021500:529847-530128 [Bacillus atrophaeus]
MSESSATTEMMISLPEALVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSATTEMMISLPEALVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT76710 NZ_CP021500:529847-530128 [Bacillus atrophaeus]
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 4MDX | |
PDB | 4ME7 | |
PDB | 1NE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837XXL9 |