Detailed information of TA system TA076702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1907904..1908445
• Replicon: chromosome
• Accession: NZ_CP021467
• Organism: Komagataeibacter europaeus strain SRCM101446

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: S101446_RS08815
• Protein ID: WP_208620502.1
• Coordinates: 1908143..1908445 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: S101446_RS08810
• Protein ID: WP_087608863.1
• Coordinates: 1907904..1908146 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S101446_RS08785	1903381..1904061	-	681	WP_208620501.1	HNH endonuclease	-
S101446_RS08790	1904593..1905264	-	672	WP_087608175.1	class I SAM-dependent methyltransferase	-
S101446_RS08795	1905373..1906008	+	636	WP_087608176.1	TetR family transcriptional regulator	-
S101446_RS08805	1906508..1907694	+	1187	WP_118963845.1	IS3 family transposase	-
S101446_RS08810	1907904..1908146	+	243	WP_087608863.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
S101446_RS08815	1908143..1908445	+	303	WP_208620502.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
S101446_RS17710	1909749..1910300	-	552	WP_157684841.1	hypothetical protein	-
S101446_RS08825	1910343..1912304	-	1962	WP_087608178.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1892354..1914481	22127
	-	inside	IScluster/Tn	-	-	1906508..1913704	7196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11506.06 Da
• Isoelectric Point: 6.8694

>T76702 WP_208620502.1 NZ_CP021467:1908143-1908445 [Komagataeibacter europaeus]
VMRFLLRPAAQADLSAIWDYSAQRWGTTQADDYVRAIGRACQDLADGTRHGRTADDIREGYLKMLVGSHLLFFRVNENGF
IDVIRILHERMDPTRHMTDV

Nucleotide

• Length: 303 bp

>T76702 NZ_CP021467:1908143-1908445 [Komagataeibacter europaeus]
GTGATGCGTTTCCTCTTAAGGCCAGCGGCTCAAGCCGATCTGTCAGCAATCTGGGATTATTCAGCACAACGATGGGGCAC
CACTCAGGCCGATGACTATGTTCGAGCTATTGGGCGAGCCTGTCAGGATCTTGCGGACGGAACACGGCATGGACGGACTG
CCGACGATATTCGGGAAGGGTATCTCAAGATGCTCGTCGGCTCTCATCTGCTTTTTTTTCGGGTAAACGAGAATGGCTTT
ATCGACGTAATCCGCATTCTGCACGAGCGTATGGACCCCACACGCCATATGACGGATGTCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8859.85 Da
• Isoelectric Point: 4.7962

>AT76702 WP_087608863.1 NZ_CP021467:1907904-1908146 [Komagataeibacter europaeus]
MARNTSISLGDHFADFVDQQVKGGRYGSASDVVRAGLRILEERETRLETLRSALIDGEQSGAAEPFDIEDFLATKAKQFR

Nucleotide

• Length: 243 bp

>AT76702 NZ_CP021467:1907904-1908146 [Komagataeibacter europaeus]
ATGGCACGCAACACATCAATCTCACTCGGCGACCATTTCGCAGATTTCGTAGACCAGCAGGTAAAAGGTGGACGCTACGG
CTCAGCGAGCGACGTCGTACGCGCTGGCCTGCGGATTCTTGAAGAGCGGGAGACACGACTTGAAACTCTTCGCTCTGCCC
TGATCGACGGCGAGCAGTCCGGTGCAGCCGAGCCGTTCGATATAGAAGATTTCCTCGCCACGAAGGCTAAACAGTTCCGG
TGA