Detailed information of TA system TA076701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1849692..1850221
• Replicon: chromosome
• Accession: NZ_CP021467
• Organism: Komagataeibacter europaeus strain SRCM101446

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: S101446_RS08510
• Protein ID: WP_208620495.1
• Coordinates: 1849985..1850221 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: S101446_RS08505
• Protein ID: WP_087608129.1
• Coordinates: 1849692..1849934 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S101446_RS08495	1845036..1848278	-	3243	WP_087608127.1	RNA-directed DNA polymerase	-
S101446_RS08500	1848275..1849309	-	1035	WP_165829430.1	toprim domain-containing protein	-
S101446_RS08505	1849692..1849934	+	243	WP_087608129.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
S101446_RS08510	1849985..1850221	+	237	WP_208620495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
S101446_RS08515	1850254..1850520	-	267	WP_087608130.1	DUF2274 domain-containing protein	-
S101446_RS08520	1850517..1851725	-	1209	WP_087608131.1	TrbI/VirB10 family protein	-
S101446_RS08525	1851722..1852723	-	1002	WP_087608132.1	P-type conjugative transfer protein TrbG	-
S101446_RS08530	1852720..1853403	-	684	WP_087608860.1	conjugal transfer protein TrbF	-
S101446_RS08535	1853409..1854794	-	1386	WP_087608133.1	P-type conjugative transfer protein TrbL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-71)

Antitoxin

• Antitoxin ParD (3-58)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9283.65 Da
• Isoelectric Point: 7.0738

>T76701 WP_208620495.1 NZ_CP021467:1849985-1850221 [Komagataeibacter europaeus]
VRDFGPRQAEIYHAGLADAFDLIASHPQLAPERREFDPPIRLHRHRAHHILYLIDDDGVLIVRMLPRLRRWERLIETD

Nucleotide

• Length: 237 bp

>T76701 NZ_CP021467:1849985-1850221 [Komagataeibacter europaeus]
GTGAGGGATTTTGGGCCACGGCAGGCCGAAATCTACCATGCAGGACTGGCAGACGCGTTCGACCTTATTGCCTCACATCC
GCAGCTTGCGCCGGAACGTCGTGAGTTCGACCCACCGATACGGCTCCACCGTCATCGGGCTCACCATATCCTCTATCTCA
TTGACGACGATGGGGTTCTGATCGTCCGCATGCTGCCCCGACTACGGCGCTGGGAGCGGCTTATAGAAACAGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8731.81 Da
• Isoelectric Point: 5.7808

>AT76701 WP_087608129.1 NZ_CP021467:1849692-1849934 [Komagataeibacter europaeus]
MATMNVSLPAPMKEWVEAQAKTGRYSNASDYVRDLIRRDQEARAAPDEVQAHITAGVGTRSMKQLLQDARAIAGTTDADL

Nucleotide

• Length: 243 bp

>AT76701 NZ_CP021467:1849692-1849934 [Komagataeibacter europaeus]
ATGGCAACAATGAACGTATCCCTGCCCGCCCCCATGAAGGAATGGGTAGAGGCTCAGGCCAAGACGGGACGCTATAGCAA
TGCGAGCGACTATGTTCGCGATCTGATCCGGCGAGATCAGGAGGCCCGTGCGGCGCCTGACGAGGTTCAGGCCCACATCA
CGGCCGGTGTGGGGACCAGAAGCATGAAGCAGTTGCTGCAGGATGCTCGCGCGATTGCCGGGACAACGGATGCCGACCTA
TAG