Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1900983..1901814 Replicon chromosome
Accession NZ_CP021454
Organism Escherichia coli strain H105

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag CCL28_RS09460 Protein ID WP_000854815.1
Coordinates 1900983..1901357 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag CCL28_RS09465 Protein ID WP_001280918.1
Coordinates 1901446..1901814 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCL28_RS09425 1896379..1897545 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
CCL28_RS09430 1897664..1898137 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
CCL28_RS09435 1898335..1899393 + 1059 WP_001200889.1 FUSC family protein -
CCL28_RS09440 1899565..1899894 + 330 WP_000450409.1 DUF496 family protein -
CCL28_RS09445 1899995..1900177 - 183 WP_001296208.1 hypothetical protein -
CCL28_RS09450 1900231..1900377 + 147 Protein_1748 transposase domain-containing protein -
CCL28_RS26760 1900666..1900779 - 114 WP_001161660.1 DUF957 domain-containing protein -
CCL28_RS09455 1900792..1900986 - 195 WP_000988600.1 hypothetical protein -
CCL28_RS09460 1900983..1901357 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
CCL28_RS09465 1901446..1901814 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CCL28_RS09470 1901830..1902474 - 645 WP_000086752.1 hypothetical protein -
CCL28_RS09475 1902493..1902714 - 222 WP_000692345.1 DUF987 domain-containing protein -
CCL28_RS09480 1902777..1903253 - 477 WP_001186200.1 RadC family protein -
CCL28_RS09485 1903269..1903742 - 474 WP_001542276.1 antirestriction protein -
CCL28_RS09490 1903836..1904081 - 246 WP_001164966.1 hypothetical protein -
CCL28_RS09495 1904081..1904899 - 819 WP_001542275.1 DUF945 domain-containing protein -
CCL28_RS09505 1905120..1905530 - 411 WP_000846703.1 hypothetical protein -
CCL28_RS09510 1905546..1905896 - 351 Protein_1760 hypothetical protein -
CCL28_RS09515 1905979..1906725 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T76681 WP_000854815.1 NZ_CP021454:c1901357-1900983 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T76681 NZ_CP021454:c1901357-1900983 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT76681 WP_001280918.1 NZ_CP021454:c1901814-1901446 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT76681 NZ_CP021454:c1901814-1901446 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References