Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2066341..2066946 Replicon chromosome
Accession NZ_CP021434
Organism Tumebacillus avium strain AR23208

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag CBW65_RS09885 Protein ID WP_087456648.1
Coordinates 2066596..2066946 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CBW65_RS09880 Protein ID WP_087459185.1
Coordinates 2066341..2066592 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBW65_RS09860 2062981..2063385 + 405 WP_087456644.1 hotdog fold thioesterase -
CBW65_RS09865 2063382..2063759 + 378 WP_087456645.1 holo-ACP synthase -
CBW65_RS09870 2063902..2064909 + 1008 WP_087456646.1 outer membrane lipoprotein-sorting protein -
CBW65_RS09875 2065044..2066189 + 1146 WP_198299844.1 alanine racemase -
CBW65_RS09880 2066341..2066592 + 252 WP_087459185.1 ribbon-helix-helix protein, CopG family Antitoxin
CBW65_RS09885 2066596..2066946 + 351 WP_087456648.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CBW65_RS09890 2067059..2067340 - 282 WP_087456649.1 hypothetical protein -
CBW65_RS09895 2068021..2070645 + 2625 WP_087456650.1 alanine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.91 Da        Isoelectric Point: 5.1342

>T76624 WP_087456648.1 NZ_CP021434:2066596-2066946 [Tumebacillus avium]
VNVKRGDIYFADLSPVVGSEQGGFRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGLDRDSVILLEQV
RTIDKQRLTDKITHLDDELMARVNESLMISLGLIEF

Download         Length: 351 bp

>T76624 NZ_CP021434:2066596-2066946 [Tumebacillus avium]
GTGAATGTAAAGCGCGGCGACATCTATTTTGCCGATTTATCGCCCGTCGTAGGTTCCGAGCAGGGCGGGTTTCGACCGGT
CCTCATCATACAGAACGACATCGGCAATCGATTTAGTCCAACGGTGATTGTCGCGGCGATTACCGCGCAGATTCAAAAGG
CGAAACTGCCTACCCATGTGGAAATAGACGCAAAAACGTACGGTTTGGATCGTGATTCCGTAATTCTGTTGGAACAAGTC
CGCACGATTGATAAGCAGCGGTTGACCGATAAGATCACTCATCTCGACGATGAGCTGATGGCAAGAGTAAACGAATCTCT
GATGATCTCCTTAGGACTTATCGAGTTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9626.00 Da        Isoelectric Point: 4.6892

>AT76624 WP_087459185.1 NZ_CP021434:2066341-2066592 [Tumebacillus avium]
MVSVPNHLLQEVDGIVEKENLNRSEFIREAMNLYLQERKKRYIRESLQKGYLEMAKINLNIASEAFLAEEEAETTLDRLV
SGV

Download         Length: 252 bp

>AT76624 NZ_CP021434:2066341-2066592 [Tumebacillus avium]
ATGGTTAGTGTACCGAATCATCTTTTGCAGGAAGTGGACGGCATTGTGGAGAAGGAAAACCTGAACCGCAGCGAGTTCAT
TCGCGAGGCGATGAACCTGTATCTGCAAGAGAGAAAGAAGCGTTATATCCGGGAGTCTCTGCAAAAAGGCTATCTGGAGA
TGGCGAAGATTAACCTAAACATCGCATCAGAAGCGTTTTTGGCGGAGGAAGAGGCGGAGACAACTCTAGACCGTTTAGTT
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References