Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3922..4465 Replicon plasmid pSMR4r-1
Accession NZ_CP021432
Organism Yoonia vestfoldensis strain SMR4r

Toxin (Protein)


Gene name parE Uniprot ID A0A521F637
Locus tag LOKVESSMR4R_RS19290 Protein ID WP_009827038.1
Coordinates 3922..4221 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A521F6B6
Locus tag LOKVESSMR4R_RS19295 Protein ID WP_009827037.1
Coordinates 4214..4465 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOKVESSMR4R_RS19290 3922..4221 - 300 WP_009827038.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOKVESSMR4R_RS19295 4214..4465 - 252 WP_009827037.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LOKVESSMR4R_RS19300 4516..5160 - 645 WP_009827036.1 hypothetical protein -
LOKVESSMR4R_RS19305 5266..5742 - 477 WP_009827035.1 hypothetical protein -
LOKVESSMR4R_RS19310 5744..6127 - 384 WP_009827034.1 hypothetical protein -
LOKVESSMR4R_RS19315 6206..6502 - 297 WP_009827033.1 hypothetical protein -
LOKVESSMR4R_RS19320 6619..6999 - 381 WP_087213650.1 DUF3768 domain-containing protein -
LOKVESSMR4R_RS19325 7126..9297 - 2172 WP_087213653.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111030 111030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-91)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11409.91 Da        Isoelectric Point: 6.3235

>T76622 WP_009827038.1 NZ_CP021432:c4221-3922 [Yoonia vestfoldensis]
MRDIHHSQAAKSDLVDIWVETDRQWGEAQADRYLDDIDRALKGLIANPQMGSDCSDLLQGARKLITGRHLVFYEVDPDRI
FVIRVLHQSMDVPRHLRSS

Download         Length: 300 bp

>T76622 NZ_CP021432:c4221-3922 [Yoonia vestfoldensis]
ATGCGTGACATTCATCACTCTCAGGCGGCAAAATCCGACCTCGTCGATATCTGGGTCGAGACAGACCGACAGTGGGGCGA
GGCGCAGGCGGACCGCTATCTCGATGATATCGATCGCGCCCTGAAGGGTCTCATCGCCAACCCGCAAATGGGGTCTGACT
GTTCCGATCTCTTGCAGGGTGCGCGTAAACTGATCACGGGCCGGCACCTCGTGTTCTACGAGGTGGACCCGGACAGGATC
TTCGTGATCCGAGTCTTGCATCAGTCCATGGACGTGCCGAGGCATCTGCGGTCGTCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9139.30 Da        Isoelectric Point: 5.1299

>AT76622 WP_009827037.1 NZ_CP021432:c4465-4214 [Yoonia vestfoldensis]
MASTSVTLGPHWDEFIALMLKEGRYGSTSELIRASLRLMEEQEGQRARLRVALMEGKQSGDAGPLDMDEIKRDARSRSGA
SDA

Download         Length: 252 bp

>AT76622 NZ_CP021432:c4465-4214 [Yoonia vestfoldensis]
ATGGCAAGCACAAGCGTCACACTTGGCCCCCATTGGGACGAATTCATCGCCCTGATGCTTAAAGAGGGGCGTTACGGGTC
AACCAGCGAGTTGATCCGCGCCTCTCTGCGCCTGATGGAGGAGCAGGAAGGTCAGCGGGCGCGGCTTCGCGTTGCGCTGA
TGGAGGGCAAACAATCCGGTGACGCCGGTCCGCTTGACATGGATGAGATCAAGCGCGACGCGCGGAGCCGCTCTGGCGCT
TCTGATGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A521F637

Antitoxin

Source ID Structure
AlphaFold DB A0A521F6B6

References